中国儿童群体中该基因多态性与胶质瘤易感性之间的相关性。
The correlation between polymorphisms in the gene and glioma susceptibility in a Chinese pediatric population.
作者信息
Zhang Zhuorong, Huang Yihuan, Chen Honghao, Wu Ping, Deng Zhijian, Deng Gaoyan, Zheng Yongqin, Li Guoyuan, Yuan Li, Xu Yingyi
机构信息
Department of Comprehensive and Emergency Surgery, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
Department of Pathology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
出版信息
Transl Pediatr. 2021 Jul;10(7):1896-1904. doi: 10.21037/tp-21-301.
BACKGROUND
A previous study revealed that single nucleotide polymorphisms (SNPs) in coding genes play a key role in tumorigenesis, genetic disorders, and drug resistance. Xeroderma pigmentosum group C () protein is a key DNA damage recognition factor that is required for maintaining the genomic stability. However, the correlation between polymorphisms and glioma susceptibility is still unclear. Hence, this study aimed to investigate the correlation between polymorphisms and pediatric glioma susceptibility.
METHODS
A total of 399 participants (171 glioma patients and 228 controls) were enrolled to evaluate the correlation between polymorphism and pediatric glioma susceptibility. The count data of two groups was analyzed by chi-squared (χ) test. Moreover, logistic regression was used to assess the strength of polymorphisms associated with glioma susceptibility.
RESULTS
We identified that rs1870134 G>C reduced pediatric glioma susceptibility. Compared to participants with rs1870134 GG/GC genotypes, those with rs1870134 CC genotype had a significantly lower risk for glioma [adjusted odds ratio (AOR) =0.10, 95% confidence interval (CI): 0.01 to 0.78, P=0.028]. Patients with 4-5 genotypes have higher risk of glioma than those with 0-3 genotypes (AOR =1.59, 95% CI: 1.04 to 2.43, P=0.031). The stratified analysis showed that the risky effects of rs2228000 CT/TT genotypes and rs2229090 GC/CC genotypes were more predominant among children aged ≥60 months, astrocytic tumors, and clinical stage I.
CONCLUSIONS
We found for the first time that polymorphisms had a statistically significant correlation with pediatric glioma susceptibility in a Chinese population. The rs2228000 CT/TT and rs2229090 GC/CC genotypes could both increase the risk of pediatric glioma in subgroups with females, astrocytic tumors, and clinical stage I. The polymorphism has potential to be a useful adjunct method to screen pediatric glioma.
背景
先前的一项研究表明，编码基因中的单核苷酸多态性（SNP）在肿瘤发生、遗传疾病和耐药性中起关键作用。着色性干皮病C组（XPC）蛋白是维持基因组稳定性所需的关键DNA损伤识别因子。然而，XPC多态性与胶质瘤易感性之间的相关性仍不清楚。因此，本研究旨在探讨XPC多态性与儿童胶质瘤易感性之间的相关性。
方法
共纳入399名参与者（171例胶质瘤患者和228名对照），以评估XPC多态性与儿童胶质瘤易感性之间的相关性。两组的计数资料采用卡方（χ²）检验进行分析。此外，采用逻辑回归评估XPC多态性与胶质瘤易感性的关联强度。
结果
我们发现XPC rs1870134 G>C降低了儿童胶质瘤易感性。与rs1870134 GG/GC基因型的参与者相比，rs1870134 CC基因型的参与者患胶质瘤的风险显著降低[调整优势比（AOR）=0.10，95%置信区间（CI）：0.01至0.78，P=0.028]。XPC基因型为4 - 5型的患者患胶质瘤的风险高于基因型为0 - 3型的患者（AOR =1.59，95% CI：1.04至2.43，P=0.031）。分层分析表明，rs2228000 CT/TT基因型和rs2229090 GC/CC基因型的风险效应在年龄≥60个月的儿童、星形细胞瘤和临床I期患者中更为显著。
结论
我们首次发现，在中国人群中，XPC多态性与儿童胶质瘤易感性存在统计学上的显著相关性。XPC rs2228000 CT/TT和rs2229090 GC/CC基因型均可增加女性、星形细胞瘤和临床I期亚组儿童患胶质瘤的风险。XPC多态性有可能成为筛查儿童胶质瘤的一种有用辅助方法。
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