Tiller J W, Schweitzer I, Maguire K P, Davis B
Department of Psychiatry, Univerisity of Melbourne.
Br J Psychiatry. 1989 Oct;155:483-9. doi: 10.1192/bjp.155.4.483.
In double-blind sequential study, diazepam was compared with the proven antidepressant moclobemide, in patients with atypical depression. Both agents significantly improved depression ratings over eight weeks of treatment. Diazepam was a significantly better antidepressant than moclobemide at four week, although not at eight weeks. All patients ceased diazepam within one year and none reported withdrawal reactions. These data suggest the need to reconsider that benzodiazepines may be antidepressants and to study their possible antidepressant actions.
在双盲序贯研究中，将地西泮与已证实有效的抗抑郁药吗氯贝胺用于非典型抑郁症患者进行比较。在为期八周的治疗中，两种药物均显著改善了抑郁评分。在治疗四周时，地西泮作为抗抑郁药的效果显著优于吗氯贝胺，但在八周时并非如此。所有患者在一年内停用了地西泮，且无人报告有戒断反应。这些数据表明有必要重新考虑苯二氮䓬类药物可能是抗抑郁药，并研究其可能的抗抑郁作用。
