Van Look P F, Bygdeman M
Bull World Health Organ. 1989;67(5):567-75.
Termination of early pregnancy by vacuum aspiration is a well-established technique. The procedure is highly effective and has a low complication rate, particularly when performed during the first few weeks after missed menses. However, this parasurgical method requires skilled health care personnel, and attempts have therefore been made to find medical alternatives. Prostaglandins were the first agents to be used successfully for this purpose, but the high incidence of mainly gastrointestinal side-effects has limited their widespread use. More recently, attention has focused on antiprogestational steroids, i.e., compounds that prevent the action of progesterone either by inhibiting its biosynthesis or by preventing it from binding to the cellular receptors in target organs. Current experience indicates that these compounds, particularly when used in combination with a low dose of a synthetic prostaglandin analogue, have the potential to become a safe, effective, and acceptable medical method for the termination of early pregnancy.
负压吸宫术终止早期妊娠是一项成熟的技术。该手术非常有效且并发症发生率低，尤其是在月经推迟后的头几周进行时。然而，这种类似外科手术的方法需要熟练的医护人员，因此人们一直在尝试寻找医学替代方法。前列腺素是最早成功用于此目的的药物，但主要是胃肠道副作用的高发生率限制了它们的广泛使用。最近，注意力集中在抗孕激素类固醇上，即通过抑制其生物合成或阻止其与靶器官中的细胞受体结合来阻止孕酮作用的化合物。目前的经验表明，这些化合物，特别是与低剂量合成前列腺素类似物联合使用时，有可能成为一种安全、有效且可接受的早期妊娠终止医学方法。
