Elhennawi D M, Ahmed M R, Abou-Halawa A S
Department of Otorhinolaryngology, Faculty of medicine, Suez Canal University, Ismailia, Egypt.
Clin Otolaryngol. 2016 Dec;41(6):758-761. doi: 10.1111/coa.12640. Epub 2016 Mar 14.
To study the correlation of obstructive sleep apnoea (OSA) and laryngopharyngeal reflux (LPR).
A descriptive study.
Suez Canal University Hospital, Ismailia, Egypt.
62 patients with polysomnography confirmed OSA.
Patients were evaluated with ambulatory 24-h double channel pH monitoring.
Mean reflux symptom index in the study group was 9 ± 5.5, and it was > 13 in all patients with severe OSA. Signs of LPR reflux were present in 34 (55%) patients. Abnormal reflux was detected in the distal oesophagus in 41 patients (66%) and in the proximal oesophagus in 21 patients (34%). Patients with severe OSA had significantly higher nocturnal LPR reflux episodes compared to patients with mild disease (P < .05). Number of reflux episodes and total duration of reflux during sleep are significantly correlated to degree of OSA (P < .05). No difference was found in relation to age or sex. Daytime reflux was not related to the degree of obstructive sleep apnoea (P > .05).
LPR is common in patients with OSA. Patients with severe OSA have significantly higher nocturnal LPR. This should be considered when treating this group of patients.
研究阻塞性睡眠呼吸暂停（OSA）与喉咽反流（LPR）之间的相关性。
一项描述性研究。
埃及伊斯梅利亚的苏伊士运河大学医院。
62例经多导睡眠图确诊为OSA的患者。
对患者进行24小时动态双通道pH监测评估。
研究组的平均反流症状指数为9±5.5，所有重度OSA患者的该指数均>13。34例（55%）患者存在LPR反流体征。41例（66%）患者在食管远端检测到异常反流，21例（34%）患者在食管近端检测到异常反流。与轻度OSA患者相比，重度OSA患者夜间LPR反流发作明显更多（P<.05）。反流发作次数和睡眠期间反流总时长与OSA程度显著相关（P<.05）。在年龄或性别方面未发现差异。白天反流与阻塞性睡眠呼吸暂停程度无关（P>.05）。
LPR在OSA患者中很常见。重度OSA患者夜间LPR明显更高。在治疗这类患者时应考虑到这一点。
