Erdem Duygu, Yılmaz Yavuz Fuat, Özcan Müge, Titiz Ali, Özlügedik Samet, Ünal Adnan
Department of Otorhinolaryngology, Faculty of Medicine, Bülent Ecevit University, Zonguldak, Turkey.
Department of Otorhinolaryngology, Health Sciences University, Gülhane Faculty of Medicine, Ankara, Turkey.
Eur Arch Otorhinolaryngol. 2018 Oct;275(10):2585-2592. doi: 10.1007/s00405-018-5107-0. Epub 2018 Aug 28.
To investigate the relationship between sleep-disordered breathing with gastroesophageal reflux (GER) and laryngopharyngeal reflux (LPR) using a two-channel triple-sensor pHmetry catheter.
The study was carried out on a total of 34 people with complaints of snoring, witnessed apnea and daytime sleepiness. 24-h pH monitoring with a two-channel, triple-sensor antimony pH catheter was applied to individuals simultaneously with polysomnography (PSG) on the day they would sleep in the sleep laboratory. Obstructive sleep apnea syndrome (OSAS) severity and reflux grade were compared with each other. Data obtained from PSG and pHmetry results were numerically compared with each other. The relationship between apnea, hypopnea, and arousal periods and reflux episodes was then examined by overlaying pHmetry graphics for each patient.
A total of 34 individuals (18 males-52.9% and 16 females-47.1%), age ranging from 27 to 71 years (mean 50.5 ± 11.0) participated in the study. GER was detected in 52.9% and LPR in 85.3% of the patients. In 35.3% of cases, pathologic GER was not observed despite LPR detection. No statistically significant relationship was found between the numerical values of apnea-hypopnea index (AHI) and arousal numbers and reflux parameters of individuals and between OSAS severity and LPR and GER (p > 0.05). There was no statistically significant correlation between respiratory events and reflux episodes with regard to timing (p > 0.05).
The prevalence of GER and LPR is found to be high in patients with sleep-disordered breathing. There is no significant relationship between OSAS severity and GER and LPR grade or respiratory events and reflux episodes with regard to timing.
使用双通道三传感器pH值监测导管，研究睡眠呼吸障碍与胃食管反流（GER）和喉咽反流（LPR）之间的关系。
对总共34名主诉打鼾、有呼吸暂停目睹史和日间嗜睡的患者进行了研究。在他们于睡眠实验室睡觉的当天，对个体同时应用双通道、三传感器锑pH值导管进行24小时pH监测和多导睡眠图（PSG）检查。比较阻塞性睡眠呼吸暂停综合征（OSAS）严重程度和反流分级。将从PSG获得的数据和pH值监测结果进行数值比较。然后通过叠加每位患者的pH值监测图形，检查呼吸暂停、呼吸浅慢和觉醒期与反流发作之间的关系。
共有34名个体（18名男性，占52.9%；16名女性，占47.1%）参与了研究，年龄在27至71岁之间（平均50.5±11.0岁）。52.9%的患者检测到GER, 85.3%的患者检测到LPR。在35.3%的病例中，尽管检测到LPR，但未观察到病理性GER。个体的呼吸暂停低通气指数（AHI）和觉醒次数的数值与反流参数之间，以及OSAS严重程度与LPR和GER之间均未发现统计学上的显著关系（p>0.05）。在时间方面，呼吸事件与反流发作之间没有统计学上的显著相关性（p>0.05）。
睡眠呼吸障碍患者中GER和LPR的患病率较高。OSAS严重程度与GER和LPR分级之间，或呼吸事件与反流发作在时间方面均无显著关系。
