Braga António Costa, Pinto Clara, Santos Ernestina, Braga Jorge
Obstetrics Department, Centro Hospitalar do Porto, Largo Prof. Abel Salazar, 4099-001, Oporto, Portugal.
Neurology Department, Centro Hospitalar do Porto, Oporto, Portugal.
Muscle Nerve. 2016 Oct;54(4):715-20. doi: 10.1002/mus.25095. Epub 2016 Jul 14.
We evaluated the clinical course during pregnancy and neonatal outcomes of a cohort of Portuguese women with myasthenia gravis (MG).
Retrospective study.
Twenty-five patients with 30 pregnancies were included. Mean maternal age was 32.4 ± 4.1 years. Miscarriage rate was 6.7%, with delivery of 28 newborns. Deterioration in MG during pregnancy occurred in 43.3%, and 46.4% occurred at postpartum. Eighty percent were medicated with pyridostigmine, 43.3% with corticosteroids, and 40% with intravenous immunoglobulin. There were no maternal or neonatal deaths. Mean gestational time at delivery was 38.2 weeks. No cases of fetal growth restriction, preeclampsia, preterm delivery, or fetal demise were observed. Global cesarean rate was 64.3%. Two newborns developed transient neonatal myasthenia.
A high rate of clinical worsening of MG in the mother was observed in this retrospective study, which highlights the importance of a multidisciplinary approach for avoiding maternal adverse outcomes. Muscle Nerve 54: 715-720, 2016.
我们评估了一组患有重症肌无力（MG）的葡萄牙女性在孕期的临床过程及新生儿结局。
回顾性研究。
纳入了25例患者的30次妊娠。产妇平均年龄为32.4±4.1岁。流产率为6.7%，分娩28例新生儿。孕期MG病情恶化的发生率为43.3%，产后为46.4%。80%的患者使用吡啶斯的明治疗，43.3%使用皮质类固醇，40%使用静脉注射免疫球蛋白。无孕产妇或新生儿死亡。分娩时的平均孕周为38.2周。未观察到胎儿生长受限、子痫前期、早产或胎儿死亡的病例。总体剖宫产率为64.3%。两名新生儿发生了短暂性新生儿重症肌无力。
在这项回顾性研究中观察到母亲MG临床病情恶化的发生率较高，这凸显了多学科方法对于避免孕产妇不良结局的重要性。《肌肉与神经》54: 715 - 720, 2016年。
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