Baker Stephen, Hombach Joachim, Marks Florian
Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam Centre for Tropical Medicine, Oxford University London School of Hygiene and Tropical Medicine, United Kingdom.
Initiative for Vaccine Research, World Health Organization, Geneva, Switzerland;
Clin Infect Dis. 2016 Mar 15;62 Suppl 1(Suppl 1):S1-3. doi: 10.1093/cid/civ675.
The Typhoid Fever Surveillance in Africa Program (TSAP) was established in 2009 to fill the data void concerning invasive Salmonella disease in sub-Saharan Africa, and to specifically estimate the burden of bloodstream infections caused by the key pathogen, Salmonella enterica serovar Typhi. TSAP has achieved this ambitious target, finding high incidences of typhoid fever in both rural and urban populations in several countries in sub-Saharan Africa. The results of TSAP will undoubtedly dictate the direction of future typhoid fever research in Africa, and at last provides a key piece of the disease burden jigsaw puzzle. With the dawn of new Vi conjugate vaccines against Salmonella Typhi, the next priority for the typhoid community must be providing the required data on these vaccines so they can be licensed and provided to those in high-risk groups and locations across sub-Saharan Africa.
非洲伤寒热监测项目（TSAP）于2009年设立，以填补撒哈拉以南非洲侵袭性沙门氏菌病的数据空白，并具体估算主要病原体伤寒沙门氏菌引起的血流感染负担。TSAP已实现这一宏伟目标，发现在撒哈拉以南非洲多个国家的农村和城市人口中伤寒热发病率都很高。TSAP的结果无疑将决定未来非洲伤寒热研究的方向，最终为疾病负担拼图提供关键的一块。随着新型抗伤寒沙门氏菌Vi结合疫苗的问世，伤寒研究领域的下一个优先事项必须是提供有关这些疫苗的所需数据，以便它们能够获得许可并提供给撒哈拉以南非洲高危群体和地区的人群。
