International Vaccine Institute, Seoul, Republic of Korea.
Graduate School of Public Health, Yonsei University, Seoul, Republic of Korea.
Sci Data. 2024 Oct 5;11(1):1089. doi: 10.1038/s41597-024-03912-x.
Typhoid fever, caused by Salmonella enterica serovar Typhi, results in over 1.2 million cases and 29 thousand deaths annually from sub-Saharan Africa. Combating this disease requires various intervention approaches, such as typhoid conjugate vaccines and improving water, sanitation, and hygiene. Enhancing the effectiveness of these strategies necessitates a deeper understanding of the variation of the typhoid fever across the target region. Although the magnitude and variation of typhoid fever at the country level have been studied globally, sub-national variation remains underexplored. To address this gap, we collected data from 229 published reports on typhoid fever occurrences in sub-Saharan Africa between January 2000 and December 2020. The dataset includes information on the year and geographical location of observation, diagnostic tests used, and the type of studies in which typhoid fever was reported. By analyzing this dataset, we can gain insights into the sub-national heterogeneity of typhoid fever's burden in the region. This knowledge will be instrumental in designing more effective intervention strategies to combat the disease.
伤寒由伤寒沙门氏菌血清型 Typhi 引起，每年导致撒哈拉以南非洲地区超过 120 万例病例和 2.9 万例死亡。抗击这种疾病需要采取多种干预措施，如伤寒结合疫苗以及改善水、环境卫生和个人卫生。为了提高这些策略的效果，需要更深入地了解目标地区伤寒的变异情况。尽管全球范围内已经研究了国家层面伤寒的严重程度和变异情况，但国家以下层面的变异情况仍未得到充分探索。为了解决这一差距，我们收集了 2000 年 1 月至 2020 年 12 月期间撒哈拉以南非洲地区 229 篇关于伤寒发生情况的已发表报告的数据。该数据集包括观察的年份和地理位置、使用的诊断测试以及报告伤寒的研究类型的信息。通过分析这个数据集，我们可以深入了解该地区伤寒负担的国家以下层面的异质性。这些知识对于设计更有效的干预策略来抗击这种疾病将是非常重要的。
