Gupta Prahlad Rai, Bansal Ankit, Singh Anupam
Department of Respiratory Medicine, NIMS Medical College and Hospital, Jaipur, Rajasthan, India.
Consultant, Respiratory Medicine, Fortis Hospital, Jaipur, Rajasthan, India.
Lung India. 2016 Jan-Feb;33(1):32-5. doi: 10.4103/0970-2113.173053.
The prevalence of asthma in Jaipur district of Rajasthan was reported as 0.96% in an earlier survey. It was far below the national average of 2.38%. It was reasoned then that this could be due to under diagnosis of asthma in the Jaipur population.
A resurvey of the symptomatics, not diagnosed as asthma at time of the original survey was, therefore, undertaken. The resurvey data were analysed and those who now fulfilled the twin criteria for diagnosis of asthma, as used in the original survey, were diagnosed as having asthma. The original data of these newly diagnosed asthma patients were reanalyzed in search for an alternative diagnostic criterion.
Of the 382 symptomatics, 344 (90%) could be resurveyed and of them, 85 now fulfilled the twin diagnostic criteria for asthma. The reanalysis of the original survey data of these patients revealed that presence of shortness of breath (SOB) had the highest sensitivity, the presence of allergic symptoms in self or the family had the highest specificity and the presence of wheezing had the highest odds ratio (OR) for diagnosing asthma. Further, the OR for diagnosing asthma increased further and was highest with the presence of SOB and 2 additional symptoms. With the use of the "symptom criteria" for diagnosis of asthma i.e. the presence of SOB with 2 additional symptoms, it would have been possible to diagnose majority of the missed cases at the time of the original survey itself.
Based on this study data it can be concluded that (a) the twin criteria for diagnosing asthma as used in earlier surveys led to under diagnosis of asthma and (b) the use of symptom criteria alone effectively checks the problem of under diagnosis of asthma. The symptom criteria are being suggested as an alternative method for use in future epidemiological surveys on asthma.
在早前的一项调查中,拉贾斯坦邦斋浦尔地区哮喘的患病率报告为0.96%。这远低于2.38%的全国平均水平。当时推断,这可能是由于斋浦尔人群中哮喘诊断不足所致。
因此,对在最初调查时未被诊断为哮喘的有症状者进行了重新调查。对重新调查的数据进行了分析,那些现在符合最初调查中使用的哮喘诊断双重标准的人被诊断为患有哮喘。对这些新诊断的哮喘患者的原始数据进行了重新分析,以寻找替代诊断标准。
在382名有症状者中,344人(90%)接受了重新调查,其中85人现在符合哮喘的双重诊断标准。对这些患者原始调查数据的重新分析显示,呼吸急促(SOB)的存在具有最高的敏感性,自身或家族中存在过敏症状具有最高的特异性,喘息的存在对哮喘诊断具有最高的优势比(OR)。此外,诊断哮喘的OR进一步增加,在存在SOB和另外两种症状时最高。使用哮喘诊断的“症状标准”,即存在SOB并伴有另外两种症状,在最初调查时就有可能诊断出大多数漏诊病例。
根据本研究数据可以得出结论:(a)早期调查中使用的哮喘诊断双重标准导致哮喘诊断不足;(b)仅使用症状标准可有效检查哮喘诊断不足的问题。建议将症状标准作为未来哮喘流行病学调查的替代方法。