Bröker Michael, Berti Francesco, Costantino Paolo
a GSK Vaccines GmbH , Marburg , Germany.
b GSK Vaccines , Siena , Italy.
Hum Vaccin Immunother. 2016 Jul 2;12(7):1808-24. doi: 10.1080/21645515.2016.1153206. Epub 2016 Mar 2.
Various glycoprotein conjugate vaccines have been developed for the prevention of invasive meningococcal disease, having significant advantages over pure polysaccharide vaccines. One of the most important features of the conjugate vaccines is the induction of a T-cell dependent immune response, which enables both the induction of immune memory and a booster response after repeated immunization. The nature of the carrier protein to which the polysaccharides are chemically linked, is often regarded as the main component of the vaccine in determining its immunogenicity. However, other factors can have a significant impact on the vaccine's profile. In this review, we explore the physico-chemical properties of meningococcal conjugate vaccines, which can significantly contribute to the vaccine's immunogenicity. We demonstrate that the carrier is not the sole determining factor of the vaccine's profile, but, moreover, that the conjugate vaccine's immunogenicity is the result of multiple physico-chemical structures and characteristics.
已开发出多种糖蛋白结合疫苗用于预防侵袭性脑膜炎球菌病，与纯多糖疫苗相比具有显著优势。结合疫苗最重要的特征之一是诱导T细胞依赖性免疫反应，这使得在重复免疫后既能诱导免疫记忆又能产生加强反应。多糖与之化学连接的载体蛋白的性质，在决定疫苗免疫原性方面通常被视为疫苗的主要成分。然而，其他因素也会对疫苗的特性产生重大影响。在本综述中，我们探讨了脑膜炎球菌结合疫苗的物理化学性质，这些性质可显著促进疫苗的免疫原性。我们证明载体并非决定疫苗特性的唯一因素，而且结合疫苗的免疫原性是多种物理化学结构和特征共同作用的结果。
