Bulkin David A, Law L Matthew, Smith David M
Department of Neurobiology and Behavior, Cornell University, Ithaca, New York.
Barrow Neurological Institute at Phoenix Children's Hospital, Phoenix, Arizona.
Hippocampus. 2016 Jul;26(7):958-71. doi: 10.1002/hipo.22579. Epub 2016 Mar 21.
Returning to a familiar context triggers retrieval of relevant memories, making memories from other contexts less likely to intrude and cause interference. We investigated the physiology that underlies the use of context to prevent interference by recording hippocampal neurons while rats learned two conflicting sets of discrimination problems, either in the same context or in two distinct contexts. Rats that learned the conflicting problem sets in the same context maintained similar neural representations, and performed poorly because conflicting memories interfered with new learning. In contrast, rats that learned in different contexts formed distinct ensemble representations and performed significantly better. We also measured trial-to-trial variation in representations and found that hippocampal activity was directly linked with performance: on trials where an old representation was active, rats were far more likely to make errors. These results show that the formation of distinct hippocampal representations is critical for contextually appropriate memory retrieval. © 2016 Wiley Periodicals, Inc.
回到熟悉的情境会触发相关记忆的检索，使来自其他情境的记忆更不容易侵入并造成干扰。我们通过在大鼠学习两组相互冲突的辨别问题时记录海马神经元活动，来研究利用情境防止干扰背后的生理机制，这些问题分别在相同情境或两个不同情境中学习。在相同情境中学习相互冲突问题集的大鼠保持了相似的神经表征，并且表现较差，因为相互冲突的记忆干扰了新的学习。相比之下，在不同情境中学习的大鼠形成了不同的集合表征，并且表现明显更好。我们还测量了表征中的逐次试验变化，发现海马体活动与表现直接相关：在旧表征活跃的试验中，大鼠犯错的可能性要大得多。这些结果表明，形成不同的海马体表征对于情境适当的记忆检索至关重要。© 2016威利期刊公司
