Suekane Shigetaka, Ueda Kousuke, Suyama Shunsuke, Hayashi Tokumasa, Toyozawa Noriyuki, Yoshitake Maki, Nishihara Kiyoaki, Sakashita Nao, Uchimura Naohisa, Matsuoka Kei
Department of Urology, Kurume University School of Medicine.
Kurume Med J. 2016;62(1-2):9-16. doi: 10.2739/kurumemedj.MS64010. Epub 2016 Mar 1.
We investigated the influence of nocturia and sleep disturbance on health-related quality of life(HRQOL) using the Medical Outcomes Study 8-item Short Form Health Survey (SF-8) in patients with nocturia. We also assessed the effect of therapeutic intervention by means of an anticholinergic agent on the results of the SF-8. One hundred and eighty-four patients who voided at least once per night were surveyed using the SF-8, Overactive Bladder Symptom Score (OABSS), Pittsburgh Sleep Quality Index (PSQI), and Epworth Sleepiness Scale (ESS). These parameters were also evaluated before and after 12 weeks of imidafenacin treatment in 51 patients with OAB accompanied by nocturia. The SF-8 physical component summary score (PCS) showed a significant decrease as nighttime voiding frequency increased. The mental health component summary score was 47.1 and 47.6 (which were lower than the standard value of 50) in the group with a nighttime frequency of once and ≥3/night, respectively. The SF-8 PCS and 6 subscales were negatively associated with nighttime voiding frequency, while the PSQI global score was positively associated with it. Imidafenacin significantly improved the OABSS, PSQI, and ESS, as well as the SF-8 score. This is the first study using the SF-8 to show that nocturia and sleep disturbance have a major influence on comprehensive HRQOL and that the SF-8 can be used to monitor HRQOL in OAB patients receiving treatment for nocturia.
我们使用医学结局研究8项简表健康调查（SF - 8），对夜尿症患者中夜尿和睡眠障碍对健康相关生活质量（HRQOL）的影响进行了调查。我们还评估了使用抗胆碱能药物进行治疗干预对SF - 8结果的影响。使用SF - 8、膀胱过度活动症症状评分（OABSS）、匹兹堡睡眠质量指数（PSQI）和爱泼华嗜睡量表（ESS），对每晚至少排尿一次的184名患者进行了调查。对51例伴有夜尿症的膀胱过度活动症患者，在使用咪达非那新治疗12周前后，也对这些参数进行了评估。随着夜间排尿频率增加，SF - 8身体成分汇总得分（PCS）显著降低。夜间排尿频率为每晚一次和≥3次的组中，心理健康成分汇总得分分别为47.1和47.6（低于标准值50）。SF - 8 PCS和6个分量表与夜间排尿频率呈负相关，而PSQI总体得分与之呈正相关。咪达非那新显著改善了OABSS、PSQI和ESS以及SF - 8评分。这是第一项使用SF - 8进行的研究，表明夜尿和睡眠障碍对综合HRQOL有重大影响，且SF - 8可用于监测接受夜尿症治疗的膀胱过度活动症患者的HRQOL。
