Chin Kai Sin, Rose Georgie E, Ervin Claire F, Ong Tee Juan, Whishaw David M, Bower Wendy F
Department of Medicine and Aged Care, The Royal Melbourne Hospital, Melbourne, Victoria, Australia.
Department of Sub-Acute Care Services, The Royal Melbourne Hospital, Melbourne, Victoria, Australia.
Australas J Ageing. 2019 Dec;38(4):242-248. doi: 10.1111/ajag.12644. Epub 2019 Mar 13.
To investigate whether treatment of overactive bladder (OAB), one comorbidity of nocturia, could reduce waking to void and improve other co-existing symptoms.
A prospective cohort study was conducted at Royal Melbourne Hospital. Participants received 12 weeks of standard treatment, including lifestyle interventions and pharmacotherapy. Outcome measures were nocturia episodes, severity of urinary urgency/incontinence, sleep quality, daytime somnolence, anxiety and depression scores, quality of life and change in blood pressure.
Twenty participants completed the study. Nocturia frequency improved by one void per night. Overactive Bladder Symptom Score, sleep quality, first uninterrupted sleep time and systolic blood pressures improved. There were no significant changes in daytime somnolence, mood or quality of life.
In this pilot study, nocturia and other co-morbid dysfunctions appeared to improve when the severity of OAB was reduced. Treatment of OAB co-morbid with nocturia reduces urinary symptoms and may improve sleep parameters and positively impact return to health.
探讨治疗夜尿症的一种合并症——膀胱过度活动症（OAB）是否能减少夜间觉醒排尿次数并改善其他并存症状。
在皇家墨尔本医院进行了一项前瞻性队列研究。参与者接受了为期12周的标准治疗，包括生活方式干预和药物治疗。观察指标包括夜尿次数、尿急/尿失禁严重程度、睡眠质量、日间嗜睡、焦虑和抑郁评分、生活质量以及血压变化。
20名参与者完成了研究。夜尿频率每晚减少了一次。膀胱过度活动症症状评分、睡眠质量、首次不间断睡眠时间和收缩压均有所改善。日间嗜睡、情绪或生活质量无显著变化。
在这项初步研究中，当OAB的严重程度降低时，夜尿症和其他合并的功能障碍似乎有所改善。治疗与夜尿症合并存在的OAB可减轻泌尿系统症状，并可能改善睡眠参数，对恢复健康产生积极影响。
