van der Does Lisette J M E, Yaksh Ameeta, Kik Charles, Knops Paul, Lanters Eva A H, Teuwen Christophe P, Oei Frans B S, van de Woestijne Pieter C, Bekkers Jos A, Bogers Ad J J C, Allessie Maurits A, de Groot Natasja M S
Translational Electrophysiology, Department of Cardiology, Erasmus Medical Center, Thorax Center, PO Box 2040, s Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands.
Department of Cardiothoracic Surgery, Erasmus Medical Center, Rotterdam, The Netherlands.
J Cardiovasc Transl Res. 2016 Jun;9(3):194-201. doi: 10.1007/s12265-016-9685-1. Epub 2016 Mar 2.
The heterogeneous presentation and progression of atrial fibrillation (AF) implicate the existence of different pathophysiological processes. Individualized diagnosis and therapy of the arrhythmogenic substrate underlying AF may be required to improve treatment outcomes. Therefore, this single-center study aims to identify the arrhythmogenic areas underlying AF by intra-operative, high-resolution, multi-site epicardial mapping in 600 patients with different heart diseases. Participants are divided into 12 groups according to the underlying heart diseases and presence of prior AF episodes. Mapping is performed with a 192-electrode array for 5-10 s during sinus rhythm and (induced) AF of the entire atrial surface. Local activation times are converted into activation and wave maps from which various electrophysiological parameters are derived. Postoperative cardiac rhythm registrations and a 5-year follow-up will show the incidence of postoperative and persistent AF. This project provides the first step in the development of a tool for individual AF diagnosis and treatment.
心房颤动（AF）的异质性表现和进展意味着存在不同的病理生理过程。可能需要对AF潜在的致心律失常基质进行个体化诊断和治疗，以改善治疗效果。因此，这项单中心研究旨在通过对600例患有不同心脏病的患者进行术中高分辨率多部位心外膜标测，来确定AF潜在的致心律失常区域。参与者根据潜在的心脏病和既往AF发作情况分为12组。在窦性心律和（诱发的）整个心房表面的AF期间，使用192电极阵列进行5 - 10秒的标测。将局部激活时间转换为激活图和波图，从中得出各种电生理参数。术后心律记录和5年随访将显示术后AF和持续性AF的发生率。该项目为开发个体AF诊断和治疗工具迈出了第一步。
