糖尿病前期绝经前高血压女性中Tie2/Akt/eNOS信号通路的异常磷酸化以及循环内皮祖细胞数量或功能的降低。
Abnormal phosphorylation of Tie2/Akt/eNOS signaling pathway and decreased number or function of circulating endothelial progenitor cells in prehypertensive premenopausal women with diabetes mellitus.
作者信息
Zeng Haitao, Jiang Yanping, Tang Hailin, Ren Zi, Zeng Gaofeng, Yang Zhen
机构信息
Center for Reproductive Medicine, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, People's Republic of China.
Department of Cardiovascular Medicine, The Second Affiliated Hospital of University of South China, Hengyang, Hunan, 421001, China.
出版信息
BMC Endocr Disord. 2016 Mar 2;16:13. doi: 10.1186/s12902-016-0093-y.
BACKGROUNDS
The number and activity of circulating endothelial progenitor cells (EPCs) in prehypertension is preserved in premenopausal women. However, whether this favorable effect still exists in prehypertensive premenopausal women with diabetes is not clear.
METHODS
This study compared the number and functional activity of circulating EPCs in normotensive or prehypertensive premenopausal women without diabetes mellitus and normotensive or prehypertensive premenopausal women with diabetes mellitus, evaluated the vascular endothelial function in each groups, and investigated the possible underlying mechanism.
RESULTS
We found that compared with normotensive premenopausal women, the number and function of circulating EPCs, as well as endothelial function evaluated by flow-mediated dilatation (FMD) in prehypertensive premenopausal women were preserved. In parallel, the Tie2/Akt/eNOS signaling pathway and the plasma NO level or NO secretion of circulating EPCs in prehypertensive premenopausal women was also retained. However, in presence of normotension or prehypertension with diabetes mellitus, the number or function of circulating EPCs and FMD in premenopausal women decreased. Similarly, the phosphorylation of Tie2/Akt/eNOS signaling pathway and the plasma NO level or NO secretion of circulating EPCs was reduced in prehypertension premenopausal with diabetes mellitus.
CONCLUSION
The present findings firstly demonstrate that the unfavorable effects of diabetes mellitus on number and activity of circulating EPCs in prehypertension premenopausal women, which is at least partially related to the abnormal phosphorylation of Tie2/Akt/eNOS signaling pathway and subsequently reduced nitric oxide bioavailability. The Tie2/Akt/eNOS signaling pathway may be a potential target of vascular protection in prehypertensive premenopausal women with diabetes mellitus.
背景
绝经前女性高血压前期循环内皮祖细胞（EPCs）的数量和活性得以保留。然而，患有糖尿病的高血压前期绝经前女性是否仍存在这种有利作用尚不清楚。
方法
本研究比较了无糖尿病的血压正常或高血压前期绝经前女性与患有糖尿病的血压正常或高血压前期绝经前女性循环EPCs的数量和功能活性，评估了每组的血管内皮功能，并探究了可能的潜在机制。
结果
我们发现，与血压正常的绝经前女性相比，高血压前期绝经前女性循环EPCs的数量和功能以及通过血流介导的血管舒张（FMD）评估的内皮功能得以保留。同时，高血压前期绝经前女性的Tie2/Akt/eNOS信号通路以及循环EPCs的血浆NO水平或NO分泌也得以保留。然而，在患有糖尿病的血压正常或高血压前期状态下，绝经前女性循环EPCs的数量或功能以及FMD降低。同样，患有糖尿病的高血压前期绝经前女性中，Tie2/Akt/eNOS信号通路的磷酸化以及循环EPCs的血浆NO水平或NO分泌减少。
结论
本研究结果首次表明，糖尿病对高血压前期绝经前女性循环EPCs的数量和活性具有不利影响，这至少部分与Tie2/Akt/eNOS信号通路的异常磷酸化以及随后一氧化氮生物利用度降低有关。Tie2/Akt/eNOS信号通路可能是患有糖尿病的高血压前期绝经前女性血管保护的潜在靶点。
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