Jolly Kate, Majothi Saimma, Sitch Alice J, Heneghan Nicola R, Riley Richard D, Moore David J, Bates Elizabeth J, Turner Alice M, Bayliss Susan E, Price Malcolm J, Singh Sally J, Adab Peymane, Fitzmaurice David A, Jordan Rachel E
Institute of Applied Health Research, University of Birmingham, Edgbaston, Birmingham, UK.
School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Edgbaston, Birmingham, UK.
Int J Chron Obstruct Pulmon Dis. 2016 Feb 17;11:305-26. doi: 10.2147/COPD.S90812. eCollection 2016.
This systematic review aimed to identify the most effective components of interventions to facilitate self-management of health care behaviors for patients with COPD. PROSPERO registration number CRD42011001588.
We used standard review methods with a systematic search to May 2012 for randomized controlled trials of self-management interventions reporting hospital admissions or health-related quality of life (HRQoL). Mean differences (MD), hazard ratios, and 95% confidence intervals (CIs) were calculated and pooled using random-effects meta-analyses. Effects among different subgroups of interventions were explored including single/multiple components and multicomponent interventions with/without exercise.
One hundred and seventy-three randomized controlled trials were identified. Self-management interventions had a minimal effect on hospital admission rates. Multicomponent interventions improved HRQoL (studies with follow-up >6 months St George's Respiratory Questionnaire (MD 2.40, 95% CI 0.75-4.04, I (2) 57.9). Exercise was an effective individual component (St George's Respiratory Questionnaire at 3 months MD 4.87, 95% CI 3.96-5.79, I (2) 0%).
While many self-management interventions increased HRQoL, little effect was seen on hospital admissions. More trials should report admissions and follow-up participants beyond the end of the intervention.
本系统评价旨在确定促进慢性阻塞性肺疾病(COPD)患者医疗保健行为自我管理的干预措施中最有效的组成部分。国际前瞻性系统评价注册库(PROSPERO)注册号:CRD42011001588。
我们采用标准的评价方法,进行系统检索至2012年5月,纳入报告了住院率或健康相关生活质量(HRQoL)的自我管理干预随机对照试验。计算平均差(MD)、风险比及95%置信区间(CI),并采用随机效应荟萃分析进行汇总。探讨不同亚组干预措施的效果,包括单组分/多组分干预以及有无运动的多组分干预。
共纳入173项随机对照试验。自我管理干预对住院率影响甚微。多组分干预改善了健康相关生活质量(随访时间>6个月的研究,圣乔治呼吸问卷(MD 2.40,95%CI 0.75 - 4.04,I² 57.9))。运动是有效的单一组分(干预3个月时圣乔治呼吸问卷MD 4.87,95%CI 3.96 - 5.79,I² 0%)。
虽然许多自我管理干预提高了健康相关生活质量,但对住院率影响不大。更多试验应报告住院情况,并在干预结束后继续随访参与者。