Na Hyeongjin, Cho Minkyoung, Chung Yeonseok
Laboratory of Immune Regulation, Research Institute for Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Korea.
Immune Netw. 2016 Feb;16(1):1-12. doi: 10.4110/in.2016.16.1.1. Epub 2016 Feb 25.
Th2 cell immunity is required for host defense against helminths, but it is detrimental in allergic diseases in humans. Unlike Th1 cell and Th17 cell subsets, the mechanism by which dendritic cells modulate Th2 cell responses has been obscure, in part because of the inability of dendritic cells to provide IL-4, which is indispensable for Th2 cell lineage commitment. In this regard, immune cells other than dendritic cells, such as basophils and innate lymphoid cells, have been suggested as Th2 cell inducers. More recently, multiple independent researchers have shown that specialized subsets of dendritic cells mediate Th2 cell responses. This review will discuss the current understanding related to the regulation of Th2 cell responses by dendritic cells and other immune cells.
Th2细胞免疫对于宿主抵御蠕虫感染是必需的，但在人类过敏性疾病中却是有害的。与Th1细胞和Th17细胞亚群不同，树突状细胞调节Th2细胞反应的机制一直不清楚，部分原因是树突状细胞无法提供IL-4，而IL-4是Th2细胞谱系定向所必需的。在这方面，除树突状细胞外的免疫细胞，如嗜碱性粒细胞和固有淋巴细胞，已被认为是Th2细胞诱导剂。最近，多个独立研究团队表明，树突状细胞的特定亚群介导Th2细胞反应。本综述将讨论目前对树突状细胞和其他免疫细胞调节Th2细胞反应的理解。
