Tekin Izel, Vgontzas Angeliki, Lewis Mechelle M, Kothari Saira, Kong Lan, Lu Yue, Vrana Kent E, Huang Xuemei
Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, PA, USA.
Department of Medicine, Pennsylvania State University College of Medicine, Hershey, PA, USA.
J Neurol Neurobiol. 2015 Jul;1(3). doi: 10.16966/2379-7150.109. Epub 2015 Jul 25.
Parkinson's disease (PD) motor symptoms are frequently asymmetric and the factors that influence the side of onset are unclear.
To explore whether peripheral injury and associated chronic limb pain may influence the side of onset.
We administered a questionnaire to 128 PD patients in a tertiary movement disorder clinic. Handedness, date and type of limb injury(s) and duration of associated pain, and date and side of onset were ascertained.
Sixty-two subjects reported limb injuries prior to the onset of PD symptoms, 30 with and 32 without chronic pain (i.e., ≥ 2 months). There was no association between injury and PD onset side overall (p=0.334). In subjects with chronic pain associated with limb injuries, however, side of injuries was associated with the side of PD symptom onset (p=0.030).
Limb injury with chronic pain may be related to the side of PD symptom onset. Future studies may shed light on the nature of this observation.
帕金森病（PD）的运动症状通常不对称，而影响发病侧的因素尚不清楚。
探讨周围损伤及相关慢性肢体疼痛是否会影响发病侧。
我们对一家三级运动障碍诊所的128例帕金森病患者进行了问卷调查。确定了利手、肢体损伤的日期和类型、相关疼痛的持续时间以及发病日期和发病侧。
62名受试者报告在帕金森病症状出现之前有肢体损伤，其中30名伴有慢性疼痛（即≥2个月），32名不伴有慢性疼痛。总体而言，损伤与帕金森病发病侧之间没有关联（p=0.334）。然而，在伴有肢体损伤相关慢性疼痛的受试者中，损伤侧与帕金森病症状发病侧相关（p=0.030）。
伴有慢性疼痛的肢体损伤可能与帕金森病症状发病侧有关。未来的研究可能会阐明这一观察结果的本质。
