超高分辨率下KIR变异的景象。
A vision of KIR variation at super resolution.
作者信息
Hammond John A, Carrington Mary, Khakoo Salim I
机构信息
The Pirbright Institute, Pirbright, Woking, Surrey, UK.
Cancer and Inflammation Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
出版信息
Immunology. 2016 Jul;148(3):249-52. doi: 10.1111/imm.12606. Epub 2016 Apr 5.
Abstract
The Ninth Killer Cell Immunoglobulin-Like Receptor (KIR) Workshop was held in Winchester, UK late in the summer of 2015. The extraordinary diversity of KIR and its functional consequences were key themes throughout the meeting. Novel sequencing technologies and new bioinformatics techniques continue to increase our understanding of the genetic diversity and evolution of the KIR; while a deeper understanding of KIR functions, including their specificity for MHC and its peptide ligands, are generating more refined models of their role in disease. Limited to 100 delegates from around the world, this intimate workshop facilitated vigorous discussion, generating new ideas for research in this ever-expanding field.
摘要
第九届杀伤细胞免疫球蛋白样受体（KIR）研讨会于2015年夏末在英国温彻斯特举行。KIR的非凡多样性及其功能影响是此次会议的关键主题。新型测序技术和新的生物信息学技术不断加深我们对KIR基因多样性和进化的理解；而对KIR功能的更深入理解，包括其对MHC及其肽配体的特异性，正在产生关于其在疾病中作用的更精确模型。此次小型研讨会仅限来自世界各地的100名代表参加，促进了热烈的讨论，为这个不断扩展的领域的研究产生了新的想法。
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