Uhrberg M, Valiante N M, Shum B P, Shilling H G, Lienert-Weidenbach K, Corliss B, Tyan D, Lanier L L, Parham P
Department of Structural Biology, Stanford University School of Medicine, California 94305, USA.
Immunity. 1997 Dec;7(6):753-63. doi: 10.1016/s1074-7613(00)80394-5.
The presence and expression of killer inhibitory receptor (KIR) and CD94:NKG2 genes from 68 donors were analyzed using molecular typing techniques. The genes encoding CD94:NKG2 receptors were present in each person, but KIR gene possession varied. Most individuals expressed inhibitory KIR for the three well-defined HLA-B and -C ligands, but noninhibitory KIR genes were more variable. Twenty different KIR phenotypes were defined. Two groups of KIR haplotypes were distinguished and occurred at relatively even frequency. Group A KIR haplotypes consist of six genes: the main inhibitory KIR, one noninhibitory KIR, and a structurally divergent KIR. Allelic polymorphism within five KIR genes was detected. Group B comprises more noninhibitory KIR genes and contains at least one additional gene not represented in group A. The KIR locus therefore appears to be polygenic and polymorphic within the human population.
采用分子分型技术分析了68名供体的杀伤细胞抑制受体（KIR）和CD94:NKG2基因的存在情况及表达。编码CD94:NKG2受体的基因在每个人中都存在，但KIR基因的拥有情况各不相同。大多数个体表达针对三种明确的HLA - B和 - C配体的抑制性KIR，但非抑制性KIR基因的变异性更大。定义了20种不同的KIR表型。区分出两组KIR单倍型，且出现频率相对均匀。A组KIR单倍型由六个基因组成：主要抑制性KIR、一个非抑制性KIR和一个结构不同的KIR。在五个KIR基因中检测到等位基因多态性。B组包含更多非抑制性KIR基因，并且含有至少一个A组中未出现过的额外基因。因此，KIR基因座在人群中似乎是多基因且多态的。
