Cui Bota, Li Pan, Xu Lijuan, Peng Zhaoyuan, Xiang Jie, He Zhi, Zhang Ting, Ji Guozhong, Nie Yongzhan, Wu Kaichun, Fan Daiming, Zhang Faming
a Medical Center for Digestive Diseases , the Second Affiliated Hospital of Nanjing Medical University , Nanjing , China.
b Key Lab of Holistic Integrative Enterology , Nanjing Medical University , Nanjing , China.
Gut Microbes. 2016 Jul 3;7(4):323-328. doi: 10.1080/19490976.2016.1151608. Epub 2016 Mar 3.
Gut dysbiosis is a characteristic of inflammatory bowel disease (IBD) and is believed to play a role in the pathogenesis of IBD. Fecal microbiota transplantation (FMT) is an effective strategy to restore intestinal microbial diversity and has been reported to have a potential therapeutic value in IBD. Our recent study reported a holistic integrative therapy called "step-up FMT strategy," which was beneficial in treating steroid-dependent IBD patients. This strategy consists of scheduled FMTs combined with steroids, anti-TNF-α antibody treatment or enteral nutrition. Herein, we will elaborate the strategy thoroughly, introducing the concept, potential indication, methodology, and safety of "step-up FMT strategy" in detail.
肠道微生物群失调是炎症性肠病（IBD）的一个特征，被认为在IBD的发病机制中起作用。粪便微生物群移植（FMT）是恢复肠道微生物多样性的有效策略，据报道在IBD中具有潜在的治疗价值。我们最近的研究报告了一种名为“逐步FMT策略”的整体综合疗法，该疗法对治疗类固醇依赖型IBD患者有益。该策略包括定期FMT与类固醇、抗TNF-α抗体治疗或肠内营养相结合。在此，我们将详细阐述该策略，详细介绍“逐步FMT策略”的概念、潜在适应症、方法和安全性。
