生物膜会导致致癌状态吗？
Do biofilms confer a pro-carcinogenic state?
作者信息
Dejea Christine M, Sears Cynthia L
机构信息
a Department of Oncology , Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutions , Baltimore , MD , USA.
b Department of Medicine , Johns Hopkins University School of Medicine, Johns Hopkins Medical Institutions , Baltimore , MD , USA.
出版信息
Gut Microbes. 2016;7(1):54-7. doi: 10.1080/19490976.2015.1121363.
Abstract
It is now widely recognized that a range of human diseases, including obesity, cancer and inflammatory bowel disease, is strongly linked to the microbiota. For decades, the microbiota has been proposed to contribute to the pathogenesis of colon cancer. Our recent work reveals that the organization of the mucosal microbiota into biofilms marks a subset of human colon cancer. Further, biofilm-positive colon mucosa in the colon cancer host yields an infrequently detected polyamine metabolite, N(1), N(12)-diacetylspermine, that deserves further study to determine its utility as a marker for colon neoplasia.
摘要
现在人们普遍认识到，包括肥胖症、癌症和炎症性肠病在内的一系列人类疾病与微生物群密切相关。几十年来，人们一直认为微生物群与结肠癌的发病机制有关。我们最近的研究表明，黏膜微生物群形成生物膜的结构是人类结肠癌的一个子集。此外，结肠癌宿主中生物膜阳性的结肠黏膜会产生一种罕见的多胺代谢产物N(1)，N(12)-二乙酰精胺，值得进一步研究以确定其作为结肠肿瘤标志物的效用。
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