Mohamed Hala I, Mokarib Hamdy A, Saad Zienab M, Abd El Ghany Wael M
Faculty of Medicine, Gastroenterology and Endemic Medicine Department, Minya University, Minya, Egypt.
BMC Gastroenterol. 2016 Mar 3;16:32. doi: 10.1186/s12876-016-0443-2.
Hepatitis C virus (HCV) is a common chronic infection that is widely associated with symptoms of fatigue and abdominal pain. The aim of the present study was to determine the prevalence of functional dyspepsia (FD) among patients with hepatitis C.
This study included 252 patients with chronic hepatitis C and 150 healthy volunteers. Clinical and laboratory data were recorded for every patient. All patients and controls were administered a questionnaire of FD according to Rome III criteria.
The percentage of patients with FD was significantly higher in patients with chronic HCV than normal controls (65.9 % vs 28.7 %, respectively). In chronic HCV patients, post prandial distention syndrome (PDS) subtype was the predominant type (86.1 %). The percentage of patients with a high fibrosis score (F2-3) and raised ALT were significantly higher in patients with FD than in patients without FD (P < 0.001; P < 0.04; respectively). A multivariate regression analysis revealed a significant association between fibrosis score, BMI and FD CONCLUSION: FD is more prevalent in patients with chronic hepatitis C. Obese chronic HCV and those with higher fibrosis scores are more likely to have FD.
丙型肝炎病毒（HCV）是一种常见的慢性感染，与疲劳和腹痛症状广泛相关。本研究的目的是确定丙型肝炎患者中功能性消化不良（FD）的患病率。
本研究纳入了252例慢性丙型肝炎患者和150名健康志愿者。记录每位患者的临床和实验室数据。所有患者和对照均根据罗马III标准接受FD问卷调查。
慢性HCV患者中FD患者的百分比显著高于正常对照（分别为65.9%和28.7%）。在慢性HCV患者中，餐后腹胀综合征（PDS）亚型是主要类型（86.1%）。FD患者中高纤维化评分（F2-3）和ALT升高的患者百分比显著高于无FD患者（分别为P < 0.001；P < 0.04）。多因素回归分析显示纤维化评分、BMI与FD之间存在显著关联。结论：FD在慢性丙型肝炎患者中更为普遍。肥胖的慢性HCV患者和纤维化评分较高的患者更有可能患有FD。
