Abdelazim Omar, Hassnine Alshymaa A, Fathy Basma, Mgdy Ahmed, Semeda Nady, Mahmoud Shereen R, Saad Zeinab M, Mahmoud Haitham A
Department of Tropical Medicine, Minia University, Egypt.
Department of Internal Medicine, Minia University, Egypt.
Ren Fail. 2024 Dec;46(1):2344651. doi: 10.1080/0886022X.2024.2344651. Epub 2024 Apr 24.
: Symptoms of dyspepsia are usually encountered by chronic kidney disease patients. Abdominal discomfort is commonly seen in CKD patients with no other causes of organic affection. to determine the prevalence of functional dyspepsia in CKD patients, and which subtype is predominant in them. This observational study included 150 CKD patients. Clinical and laboratory data were recorded for every patient. All the patients were interviewed using the ROME IV questionnaire of functional dyspepsia. Patients fulfilling criteria for functional dyspepsia were exposed to upper GI endoscopy. Overall, 73 (48.7%) of CKD patients were males and 77 (51.3%) were females with mean age of (45.71 ± 9.59) and mean BMI (26.58 ± 5.39). The frequency of functional dyspepsia among CKD patients was determined to be 14.7% (22 out of 150 patients). Among those affected by functional dyspepsia, the most prevalent subtype was found to be Epigastric Pain Syndrome (EPS), accounting for 59% (13 out of 22 cases). The most common predictor of FD in CKD patients was chronic HCV infection, hemodialysis, stage of CKD and eGFR as revealed by Univariate regression analysis. The prevalence of FD amongst CKD patients is 14.7% with EPS the predominant subtype. Male patients, HCV patients, patients with higher CKD stages and highly impaired eGFR (low eGFR) are more probable to have FD.
消化不良症状在慢性肾脏病患者中较为常见。腹部不适在无其他器质性病变原因的慢性肾脏病患者中很常见。目的是确定慢性肾脏病患者中功能性消化不良的患病率以及哪种亚型占主导。这项观察性研究纳入了150例慢性肾脏病患者。记录了每位患者的临床和实验室数据。所有患者均使用功能性消化不良的罗马IV问卷进行访谈。符合功能性消化不良标准的患者接受了上消化道内镜检查。总体而言，150例慢性肾脏病患者中，73例（48.7%）为男性，77例（51.3%）为女性，平均年龄为（45.71±9.59），平均体重指数为（26.58±5.39）。慢性肾脏病患者中功能性消化不良的发生率为14.7%（150例患者中有22例）。在受功能性消化不良影响的患者中，最常见的亚型是上腹部疼痛综合征（EPS），占59%（22例中有13例）。单因素回归分析显示，慢性肾脏病患者中功能性消化不良最常见的预测因素是慢性丙型肝炎病毒感染、血液透析、慢性肾脏病分期和估算肾小球滤过率。慢性肾脏病患者中功能性消化不良的患病率为14.7%，EPS是主要亚型。男性患者、丙型肝炎病毒感染患者、慢性肾脏病分期较高和估算肾小球滤过率严重受损（估算肾小球滤过率低）的患者更有可能患功能性消化不良。
