Loustalot Fabien, Kremer Eric J, Salinas Sara
Institut de Génétique Moléculaire de Montpellier, Université de Montpellier, Montpellier, France.
Institut de Génétique Moléculaire de Montpellier, Université de Montpellier, Montpellier, France.
Int Rev Cell Mol Biol. 2016;322:331-62. doi: 10.1016/bs.ircmb.2015.10.006. Epub 2015 Dec 23.
The coxsackievirus and adenovirus receptor (CAR) belongs to the immunoglobulin superfamily and acts as a receptor for some adenovirus types and group B coxsackieviruses. Its role is best described in epithelia where CAR participates to tight junction integrity and maintenance. Recently, several studies aimed to characterize its potential interaction with intracellular signaling pathways and highlighted several features linking CAR to gene expression. In addition, the molecular mechanisms leading to CAR-specific membrane targeting via the secretory pathway in polarized cells and its internalization are starting to be unraveled. This chapter discusses the interaction between membrane dynamics, intracellular trafficking, and signaling of CAR.
柯萨奇病毒和腺病毒受体（CAR）属于免疫球蛋白超家族，是某些腺病毒类型和B组柯萨奇病毒的受体。其作用在参与紧密连接完整性和维持的上皮细胞中表现得最为明显。最近，多项研究旨在表征其与细胞内信号通路的潜在相互作用，并突出了将CAR与基因表达联系起来的几个特征。此外，通过分泌途径在极化细胞中导致CAR特异性膜靶向及其内化的分子机制也开始被揭示。本章讨论了CAR的膜动力学、细胞内运输和信号传导之间的相互作用。
