Celton J L, Lefrère J J, Cartron J, Roquin H, Kaplan C, Rouger P, Le Pennec P Y, Salmon C
Centre de Transfusion Sanguine, Hôpital Necker-Enfants Malades, Paris, France.
Nouv Rev Fr Hematol (1978). 1989;31(3):187-8.
The purpose of this study was to determine the prevalence of granulocyte-associated immunoglobulins (GA-IgG) during the follow-up of asymptomatic human immunodeficiency virus (HIV)-infected subjects. An increase in GA-IgG was detected in 32 asymptomatic HIV seropositive subjects by a granulocyte immunofluorescence test (GIFT). At study onset, 7 (21.8%) had a positive GIFT. The prevalence of positive GIFT increased with time in the study subjects. No neutropenia was found. No significant difference was observed in subjects with positive or negative GIFT with respect to mean CD4 lymphocyte count and mean neutrophil count. The presence of GA-IgG was not associated to a positive direct antiglobulin test or of elevated platelet associated IgG.
本研究的目的是确定无症状人类免疫缺陷病毒（HIV）感染受试者随访期间粒细胞相关免疫球蛋白（GA-IgG）的流行情况。通过粒细胞免疫荧光试验（GIFT）在32名无症状HIV血清阳性受试者中检测到GA-IgG升高。在研究开始时，7名（21.8%）受试者GIFT呈阳性。研究对象中GIFT阳性的流行率随时间增加。未发现中性粒细胞减少。GIFT阳性或阴性的受试者在平均CD4淋巴细胞计数和平均中性粒细胞计数方面未观察到显著差异。GA-IgG的存在与直接抗球蛋白试验阳性或血小板相关IgG升高无关。
