Bernacka K, Tytman K, Sierakowski S
Department of Rheumatology, Medical Academy, Białystok, Poland.
Med Interne. 1989 Oct-Dec;27(4):295-301.
The lack of effective therapy of ankylosing spondylitis is a reason to search a better kind of treatment. Trials to use D-penicillamine are scarce and usually limited to a short time of observation. We studied 49 patients with ankylosing spondylitis non-responding to classical therapy. Before and during treatment periodically complex clinical and laboratory tests were performed. During 9 months of therapy a significant decrease of score and involvement of vertebral column movement measured by several tests were observed. No side effects of treatment were found during this period. It is probably partly connected with the dosage of D-penicillamine which was used. It should be underlined that during 9 months of therapy, no relapse was observed in any case. The efficacy of D-penicillamine therapy was found not only in the peripheral form of ankylosing spondylitis but also in central one. However, the therapy was more effective in the former. It seems that D-penicillamine may be an effective and safe drug in the therapy of ankylosing spondylitis.
强直性脊柱炎缺乏有效的治疗方法，这促使人们寻找更好的治疗方式。使用D-青霉胺的试验很少，而且通常观察时间较短。我们研究了49例对传统治疗无反应的强直性脊柱炎患者。在治疗前和治疗期间定期进行复杂的临床和实验室检查。在9个月的治疗期间，通过多项测试观察到脊柱运动评分和受累程度显著下降。在此期间未发现治疗的副作用。这可能部分与所使用的D-青霉胺剂量有关。应该强调的是，在9个月的治疗期间，未观察到任何一例复发。发现D-青霉胺治疗不仅对周围型强直性脊柱炎有效，对中枢型也有效。然而，该治疗对前者更有效。看来D-青霉胺可能是治疗强直性脊柱炎的一种有效且安全的药物。
