Steven M M, Morrison M, Sturrock R D
J Rheumatol. 1985 Aug;12(4):735-7.
A double blind placebo controlled trial was carried out over a 6-month period on 17 patients with ankylosing spondylitis (AS) to assess the effect of the second line antirheumatic drug, D-penicillamine. The patients included 13 with peripheral joint involvement. No significant improvement over placebo was detected in a variety of clinical and laboratory indices in the patients receiving active treatment. This controlled trial would not support a use for penicillamine in AS.
一项双盲安慰剂对照试验在17名强直性脊柱炎（AS）患者中进行，为期6个月，以评估二线抗风湿药物D-青霉胺的疗效。这些患者中有13名伴有外周关节受累。在接受积极治疗的患者中，各种临床和实验室指标均未发现相对于安慰剂有显著改善。这项对照试验不支持在强直性脊柱炎中使用青霉胺。
