School of Pharmacy, Monash University Malaysia, Bandar Sunway, Selangor, Malaysia.
Jeffrey Cheah School of Medicine, Monash University Malaysia, Bandar Sunway, Selangor, Malaysia.
Sleep Med Rev. 2017 Feb;31:91-101. doi: 10.1016/j.smrv.2016.02.001. Epub 2016 Feb 9.
Recent epidemiological studies have suggested that there is an association between glycemic control and sleep disturbances in patients with type 2 diabetes, but the extent is unclear. A systematic literature search was performed in nine electronic databases from inception until August 2015 without any language restriction. The search identified 20 studies (eight studies reporting duration of sleep and 15 studies evaluating sleep quality), and 15 were included in the meta-analysis. Short and long sleep durations were associated with an increased hemoglobin A (HbA1c) (weighted mean difference (WMD): 0.23% [0.10-0.36], short sleep; WMD: 0.13% [0.02-0.25], long sleep) compared to normal sleep, suggesting a U-shaped dose-response relationship. Similarly, poor sleep quality was associated with an increased HbA1c (WMD: 0.35% [0.12-0.58]). Results of this study suggest that amount of sleep as well as quality of sleep is important in the metabolic function of type 2 diabetes patients. Further studies are needed to identify for the potential causal role between sleep and altered glucose metabolism.
最近的流行病学研究表明，2 型糖尿病患者的血糖控制与睡眠障碍之间存在关联，但关联程度尚不清楚。本研究系统地检索了从建库至 2015 年 8 月的 9 个电子数据库，未对语言进行任何限制。共检索到 20 项研究（8 项研究报告了睡眠时间，15 项研究评估了睡眠质量），其中 15 项研究纳入荟萃分析。与正常睡眠相比，短时间和长时间睡眠与糖化血红蛋白（HbA1c）升高相关（加权均数差（WMD）：0.23%[0.10-0.36]，短时间睡眠；WMD：0.13%[0.02-0.25]，长时间睡眠），提示存在 U 形剂量反应关系。同样，睡眠质量差与 HbA1c 升高相关（WMD：0.35%[0.12-0.58]）。本研究结果表明，睡眠量和睡眠质量对 2 型糖尿病患者的代谢功能很重要。需要进一步的研究来确定睡眠与葡萄糖代谢改变之间的潜在因果关系。
