Kang Lin-Lin, Chen Pei-En, Tung Tao-Hsin, Chien Ching-Wen
Institute for Hospital Management, Tsing Hua University, Shenzhen, China.
Institute of Health Policy and Management, National Taiwan University, Taipei, Taiwan.
Front Allergy. 2021 Dec 1;2:741135. doi: 10.3389/falgy.2021.741135. eCollection 2021.
The purpose of this study was to determine the association between asthma and migraine and assess the risk for migraine in patients with asthma. We systematically searched the Cochrane Library, PubMed, Medical Literature Analysis and Retrieval System Online (MEDLINE), and Excerpta Medica dataBASE (EMBASE) databases from inception to September 26, 2021, for indexed observational studies that examined either the odds or risk of migraine in subjects with asthma. The qualities of the included studies were evaluated using the Newcastle-Ottawa Scale. A random-effects meta-analysis was performed to calculate the odds ratio for case-control and cross-sectional studies and the risk ratio for cohort studies. Seven observational studies (four cross-sectional and three cohort studies) with a total of 549,534 study subjects were included in this systematic review and meta-analysis and selected for data extraction. Four articles were considered to be of moderate quality; other studies were considered to be of high quality. Asthma was associated with increased odds (OR, 1.85; 95%CI, 1.39-2.45) and risk of migraine (RR, 1.70; 95%CI, 1.52-1.90). The available evidence that supports the existence of an association between asthma and migraine is limited. Clinicians should be aware that patients with asthma show both increased prevalence and incidence of migraine. Further studies are warranted to further clarify the relationship between asthma and migraine. https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=185881, identifier: CRD42020185881.
本研究的目的是确定哮喘与偏头痛之间的关联，并评估哮喘患者患偏头痛的风险。我们系统检索了考克兰图书馆、PubMed、医学文献分析与联机检索系统（MEDLINE）以及医学文摘数据库（EMBASE），检索时间从建库至2021年9月26日，以查找索引的观察性研究，这些研究考察了哮喘患者患偏头痛的比值比或风险。使用纽卡斯尔-渥太华量表评估纳入研究的质量。进行随机效应荟萃分析，以计算病例对照研究和横断面研究的比值比以及队列研究的风险比。本系统评价和荟萃分析纳入了7项观察性研究（4项横断面研究和3项队列研究），共有549,534名研究对象，并选择进行数据提取。4篇文章被认为质量中等；其他研究被认为质量较高。哮喘与偏头痛的比值比增加（OR，1.85；95%CI，1.39 - 2.45）和风险增加（RR，1.70；95%CI，1.52 - 1.90）相关。支持哮喘与偏头痛之间存在关联的现有证据有限。临床医生应意识到哮喘患者偏头痛的患病率和发病率均有所增加。有必要进一步开展研究以进一步阐明哮喘与偏头痛之间的关系。https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=185881，标识符：CRD42020185881。
