非啮齿类单克隆抗体在兽医学中的生产与应用。
The production and application of non-rodent monoclonal antibodies in veterinary science.
作者信息
Groves D J, Tucker E M
机构信息
Department of Biochemistry, University of Surrey, Guildford, Great Britain.
出版信息
Vet Immunol Immunopathol. 1989 Nov 30;23(1-2):1-14. doi: 10.1016/0165-2427(89)90105-0.
The requirement for monoclonal antibodies derived from species other than rats and mice is becoming increasingly realised in veterinary, as well as human, medicine. This paper reviews current knowledge of the production of inter-species hybridomas (heterohybridomas) by the fusion of rodent myeloma cell lines with lymphocytes from species of veterinary importance. To date a number of monoclonal immunoglobulins derived from sheep, cattle, pig, rabbit, mink and primate species have been produced to a variety of different bacterial, viral and nematode pathogens as well as to blood group and MHC determinants and to hormones. The technique opens up a number of possibilities for the future; some of these applications are discussed in relation to the antibodies produced thus far.
在兽医学以及人类医学中，对源自大鼠和小鼠以外物种的单克隆抗体的需求正日益得到认可。本文综述了通过将啮齿动物骨髓瘤细胞系与具有兽医重要性的物种的淋巴细胞融合来生产种间杂交瘤（异种杂交瘤）的现有知识。迄今为止，已经针对多种不同的细菌、病毒和线虫病原体以及血型、主要组织相容性复合体（MHC）决定簇和激素，生产出了源自绵羊、牛、猪、兔、貂和灵长类动物物种的多种单克隆免疫球蛋白。该技术为未来开辟了许多可能性；其中一些应用结合迄今产生的抗体进行了讨论。
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