Nguyen Diep, Adnan Nik Nik M, Oliver Susan, Boyer Cyrille
Centre for Advanced Macromolecular Design (CAMD), School of Chemical Engineering, University of New South, WalesSydney, NSW, 2052, Australia.
Australian Centre for Nanomedicine (ACN), University of New South Wales, Sydney, NSW, 2052, Australia.
Macromol Rapid Commun. 2016 May;37(9):739-44. doi: 10.1002/marc.201500755. Epub 2016 Mar 4.
CORM-2, tricarbonyldichlororuthenium(II) dimer (Ru2 Cl4 (CO)6 ), is a common carbon monoxide releasing molecule (CORM) studied both in vitro and in vivo, but this compound possesses poor water solubility and a short half-life, which hinders its clinical development. Herein, for the first time the conjugation of CORM-2 is reported with a copolymer containing poly(4-vinylpyridine) to yield water-soluble CO-releasing polymeric nanoparticles. CORM-2 is rapidly conjugated to copolymers through pyridine groups as confirmed by inductively coupled plasma-optical emission spectroscopy and infrared spectroscopy. In comparison with free CORM-2, the copolymers functionalized with CORM-2 display better water solubility and the CO release from the polymer-based CORM is slow and sustained. This study paves the way for the potential use of a copolymer encapsulating CORM-2 as a therapeutic agent.
二氯四羰基钌（II）二聚体（CORM-2，Ru2Cl4(CO)6）是一种常见的一氧化碳释放分子（CORM），已在体外和体内进行了研究，但该化合物水溶性差且半衰期短，这阻碍了其临床开发。在此，首次报道了CORM-2与含聚（4-乙烯基吡啶）的共聚物共轭，以产生水溶性的一氧化碳释放聚合物纳米颗粒。电感耦合等离子体发射光谱和红外光谱证实，CORM-2通过吡啶基团迅速与共聚物共轭。与游离CORM-2相比，用CORM-2功能化的共聚物表现出更好的水溶性，并且基于聚合物的CORM释放一氧化碳的过程缓慢且持续。这项研究为将包裹CORM-2的共聚物用作治疗剂的潜在应用铺平了道路。
