Key Laboratory of Applied Surface and Colloid Chemistry MOE, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an 710062, China.
School of Materials Science and Engineering, Xi'an Jiaotong University, Xi'an 710049, China.
Int J Mol Sci. 2019 Jul 14;20(14):3453. doi: 10.3390/ijms20143453.
The pharmaceutical clay montmorillonite (MMT) is, for the first time, explored as a carbon monoxide-releasing material (CORMat). MMT consists of silicate double layered structure; its exfoliation feature intercalate the CORM-2 [RuCl(μ-Cl)(CO)] inside the layers to suppress the toxicity of organometallic segment. The infrared spectroscopy (IR) confirmed the existence of ruthenium coordinated carbonyl ligand in MMT layers. The energy-dispersive X-ray spectroscopy (EDX) analysis showed that ruthenium element in this material was about 5%. The scanning electron microscopy (SEM) and transmission electron microscope (TEM) images showed that the layer-structure of MMT has been maintained after loading the ruthenium carbonyl segment. Moreover, the layers have been stretched out, which was confirmed by X-ray diffraction (XRD) analysis. Thermogravimetric (TG) curves with huge weight loss around 100-200 °C were attributed to the CO hot-release of ruthenium carbonyl as well as the loss of the adsorbed solvent molecules and the water molecules between the layers. The CO-liberating properties have been assessed through myoglobin assay. The horse myoglobin test showed that the material could be hydrolyzed to slowly release carbon monoxide in physiological environments. The half-life of CO release was much longer than that of CORM-3, and it has an excellent environmental tolerance and slow release effect.
药用黏土蒙脱石（MMT）首次被探索作为一氧化碳释放材料（CORMat）。MMT 由硅酸盐双层结构组成；其层状结构的剥离特征将 CORM-2 [RuCl(μ-Cl)(CO)] 嵌入层间，以抑制有机金属片段的毒性。红外光谱（IR）证实了 MMT 层中存在配位羰基配体的钌。能量色散 X 射线光谱（EDX）分析表明，该材料中的钌元素约为 5%。扫描电子显微镜（SEM）和透射电子显微镜（TEM）图像显示，在负载钌羰基片段后，MMT 的层状结构得以保持。此外，通过 X 射线衍射（XRD）分析证实，层状结构已被拉伸。热重（TG）曲线在 100-200°C 左右出现巨大的重量损失归因于 Ru 羰基的 CO 热释放以及吸附溶剂分子和层间水分子的损失。通过肌红蛋白测定评估了 CO 释放性能。马肌红蛋白测试表明，该材料可在生理环境中缓慢水解以释放一氧化碳。CO 释放的半衰期明显长于 CORM-3，具有良好的环境耐受性和缓慢释放效果。
