Miles Brodie, Connick Elizabeth
Division of Infectious Diseases, University of Colorado Denver, Aurora CO 80045, USA.
Division of Infectious Diseases, University of Colorado Denver, Aurora CO 80045, USA.
Trends Microbiol. 2016 May;24(5):338-344. doi: 10.1016/j.tim.2016.02.006. Epub 2016 Mar 2.
During untreated disease, HIV replication is concentrated within T follicular helper cells (TFH). Heightened permissiveness, the presence of highly infectious virions on follicular dendritic cells (FDCs), low frequencies of virus-specific cytotoxic T lymphocytes (CTLs) in B cell follicles, expansions in TFH, and TFH dysfunction, all likely promote replication in TFH. Limited data suggest that memory TFH play a role in the latent or subclinical reservoir of HIV during antiretroviral therapy (ART), potentially for many of the same reasons. A better understanding of the role of memory TFH and FDC-bound virions in promoting recrudescent viremia in the setting of ART cessation is essential. Studies that target follicular virus reservoirs are needed to determine their role in HIV latency and to suggest successful cure strategies.
在疾病未治疗期间，HIV复制集中在滤泡辅助性T细胞（TFH）内。高易感性、滤泡树突状细胞（FDC）上存在高传染性病毒粒子、B细胞滤泡中病毒特异性细胞毒性T淋巴细胞（CTL）频率低、TFH扩增以及TFH功能障碍，所有这些都可能促进TFH中的复制。有限的数据表明，记忆性TFH在抗逆转录病毒疗法（ART）期间HIV的潜伏或亚临床储存库中发挥作用，可能是出于许多相同的原因。更好地了解记忆性TFH和FDC结合的病毒粒子在停药时促进病毒血症复发中的作用至关重要。需要针对滤泡病毒储存库的研究来确定它们在HIV潜伏中的作用，并提出成功的治愈策略。
