Department of Neurology and Psychiatry, Sapienza University of Rome, Rome, Italy; Neuromed Institute, IRCCS Pozzilli (IS), Rome, Italy.
Department of Neurology, Neuroscience Research Center, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan.
Brain Stimul. 2016 May-Jun;9(3):323-335. doi: 10.1016/j.brs.2016.01.006. Epub 2016 Jan 27.
BACKGROUND/OBJECTIVES: Over the last ten years, an increasing number of authors have used the theta burst stimulation (TBS) protocol to investigate long-term potentiation (LTP) and long-term depression (LTD)-like plasticity non-invasively in the primary motor cortex (M1) in healthy humans and in patients with various types of movement disorders. We here provide a comprehensive review of the LTP/LTD-like plasticity induced by TBS in the human M1.
A workgroup of researchers expert in this research field review and discuss critically ten years of experimental evidence from TBS studies in humans and in animal models. The review also includes the discussion of studies assessing responses to TBS in patients with movement disorders.
MAIN FINDINGS/DISCUSSION: We discuss experimental studies applying TBS over the M1 or in other cortical regions functionally connected to M1 in healthy subjects and in patients with various types of movement disorders. We also review experimental evidence coming from TBS studies in animals. Finally, we clarify the status of TBS as a possible new non-invasive therapy aimed at improving symptoms in various neurological disorders.
背景/目的：在过去的十年中，越来越多的作者使用 theta 爆发刺激（TBS）方案来非侵入性地研究原发性运动皮层（M1）中的长时程增强（LTP）和长时程抑制（LTD）样可塑性，无论是在健康人群还是各种类型运动障碍患者中。我们在此提供了 TBS 在人类 M1 中诱导的 LTP/LTD 样可塑性的综合综述。
一组在该研究领域具有专业知识的研究人员对十年来来自人类和动物模型 TBS 研究的实验证据进行了审查和批判性讨论。该综述还包括对评估运动障碍患者对 TBS 反应的研究的讨论。
主要发现/讨论：我们讨论了在健康受试者和各种类型运动障碍患者中应用于 M1 或与 M1 功能连接的其他皮质区域的 TBS 实验研究。我们还回顾了来自动物 TBS 研究的实验证据。最后，我们阐明了 TBS 作为一种新的非侵入性治疗方法的现状，旨在改善各种神经障碍的症状。
