NASA Langley Research Center, Hampton, VA 23681-2199, USA.
NASA Langley Research Center, Hampton, VA 23681-2199, USA.
Life Sci Space Res (Amst). 2016 Feb;8:52-67. doi: 10.1016/j.lssr.2016.01.001.
The galactic cosmic ray (GCR) simulator at the NASA Space Radiation Laboratory (NSRL) is intended to deliver the broad spectrum of particles and energies encountered in deep space to biological targets in a controlled laboratory setting. In this work, certain aspects of simulating the GCR environment in the laboratory are discussed. Reference field specification and beam selection strategies at NSRL are the main focus, but the analysis presented herein may be modified for other facilities and possible biological considerations. First, comparisons are made between direct simulation of the external, free space GCR field and simulation of the induced tissue field behind shielding. It is found that upper energy constraints at NSRL limit the ability to simulate the external, free space field directly (i.e. shielding placed in the beam line in front of a biological target and exposed to a free space spectrum). Second, variation in the induced tissue field associated with shielding configuration and solar activity is addressed. It is found that the observed variation is likely within the uncertainty associated with representing any GCR reference field with discrete ion beams in the laboratory, given current facility constraints. A single reference field for deep space missions is subsequently identified. Third, a preliminary approach for selecting beams at NSRL to simulate the designated reference field is presented. This approach is not a final design for the GCR simulator, but rather a single step within a broader design strategy. It is shown that the beam selection methodology is tied directly to the reference environment, allows facility constraints to be incorporated, and may be adjusted to account for additional constraints imposed by biological or animal care considerations. The major biology questions are not addressed herein but are discussed in a companion paper published in the present issue of this journal. Drawbacks of the proposed methodology are discussed and weighed against alternative simulation strategies.
美国宇航局太空辐射实验室(NSRL)的银河宇宙射线(GCR)模拟器旨在将在深空中遇到的广泛的粒子和能量输送到受控实验室环境中的生物靶标。在这项工作中,讨论了在实验室中模拟 GCR 环境的某些方面。NSRL 的参考场规范和束选择策略是主要关注点,但本文提出的分析可以针对其他设施和可能的生物学考虑进行修改。首先,对直接模拟外部自由空间 GCR 场和模拟屏蔽后面的诱导组织场进行了比较。结果发现,NSRL 上的高能限制限制了直接模拟外部自由空间场的能力(即屏蔽放置在生物靶标前面的光束线中,并暴露于自由空间谱中)。其次,解决了与屏蔽配置和太阳活动相关的诱导组织场的变化。结果发现,观察到的变化很可能在实验室中用离散离子束表示任何 GCR 参考场的不确定性范围内,考虑到当前设施的限制。随后确定了深空任务的单一参考场。第三,提出了在 NSRL 中选择束以模拟指定参考场的初步方法。这种方法不是 GCR 模拟器的最终设计,而是更广泛设计策略中的一个步骤。结果表明,束选择方法直接与参考环境相关联,允许纳入设施限制,并可以根据生物学或动物护理考虑施加的其他限制进行调整。本文未解决主要生物学问题,但在本期杂志的另一篇论文中进行了讨论。讨论了所提出的方法的缺点,并权衡了替代模拟策略。