Ghosh Sukla
Department of Biophysics, Molecular Biology and Bioinformatics, University of Calcutta, 92, A. P.C. Road, Kolkata 700 009, India,
J Biosci. 2016 Mar;41(1):157-65. doi: 10.1007/s12038-016-9589-x.
The main objective of regenerative medicine is to replenish cells or tissues or even to restore different body parts that are lost or damaged due to disease, injury and aging. Several avenues have been explored over many decades to address the fascinating problem of regeneration at the cell, tissue and organ levels. Here we discuss some of the primary approaches adopted by researchers in the context of enhancing the regenerating ability of mammals. Natural regeneration can occur in different animal species, and the underlying mechanism is highly relevant to regenerative medicine-based intervention. Significant progress has been achieved in understanding the endogenous regeneration in urodeles and fishes with the hope that they could help to reach our goal of designing future strategies for human regeneration.
再生医学的主要目标是补充细胞或组织，甚至恢复因疾病、损伤和衰老而丧失或受损的不同身体部位。几十年来，人们探索了多种途径来解决细胞、组织和器官水平上引人入胜的再生问题。在此，我们将在增强哺乳动物再生能力的背景下讨论研究人员采用的一些主要方法。自然再生可发生在不同动物物种中，其潜在机制与基于再生医学的干预密切相关。在理解蝾螈和鱼类的内源性再生方面已取得重大进展，希望它们能帮助我们实现设计人类再生未来策略的目标。
