脊椎动物晶状体再生中的细胞信号通路。
Cell signaling pathways in vertebrate lens regeneration.
机构信息
Department of Cell and Developmental Biology, University of Illinois, Urbana, IL 61801, USA.
出版信息
Curr Top Microbiol Immunol. 2013;367:75-98. doi: 10.1007/82_2012_289.
Abstract
Certain vertebrates are capable of regenerating parts of the eye, including the lens. Depending on the species, two principal forms of in vivo lens regeneration have been described wherein the new lens arises from either the pigmented epithelium of the dorsal iris or the cornea epithelium. These forms of lens regeneration are triggered by retinal factors present in the eye. Studies have begun to illuminate the nature of the signals that support lens regeneration. This review describes evidence for the involvement of specific signaling pathways in lens regeneration, including the FGF, retinoic acid, TGF-beta, Wnt, and Hedgehog pathways.
摘要
某些脊椎动物能够再生眼部的某些部位，包括晶状体。根据物种的不同，已经描述了两种主要的活体晶状体再生形式，其中新晶状体来自于虹膜背面的色素上皮或角膜上皮。这些晶状体再生形式是由眼睛中存在的视网膜因素触发的。研究已经开始阐明支持晶状体再生的信号的性质。本综述描述了特定信号通路在晶状体再生中的作用的证据，包括 FGF、视黄酸、TGF-β、Wnt 和 Hedgehog 通路。
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