Nasiri Zohreh, Sameni Hamid Reza, Vakili Abedin, Jarrahi Morteza, Khorasani Mahdi Zahedi
Research Center and Department of Physiology, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran.
Neural Stem Cells Research Center and Department of Anatomical Sciences, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran.
Iran J Basic Med Sci. 2015 Nov;18(11):1143-6.
The aim of this study was to investigate the effects of nutritional saffron (Crocus sativus L.) stigma hydroalcoholic extract on blood pressure (BP) and histology of the aorta in normotensive and hypertensive rats.
Saffron (200 mg/kg/day) was given orally for 5 weeks to normotensive and hypertensive rats. Hypertension was induced by NG-nitro-L-arginine methyl ester (L-NAME; 40 mg/kg/day) administration in drinking water, and BP was measured weekly. Histological examination of the thoracic aorta included staining with hematoxylin and eosin, orcein, and periodic acid Schiff methods.
Saffron had no effect on normotensive rats, but on hypertensive rats, prevented BP elevation form the third week of treatment (P<0.001). Furthermore, saffron reduced the cross-section area, media thickness, and elastic lamellae number of the aorta (P<0.05).
Nutritional saffron prevented BP increases and remodeling of the aorta in hypertensive rats. It may be useful for preventing hypertension.
本研究旨在探讨营养型藏红花（番红花）柱头水醇提取物对正常血压和高血压大鼠血压（BP）及主动脉组织学的影响。
将藏红花（200毫克/千克/天）口服给予正常血压和高血压大鼠，持续5周。通过在饮用水中给予NG-硝基-L-精氨酸甲酯（L-NAME；40毫克/千克/天）诱导高血压，每周测量血压。胸主动脉的组织学检查包括苏木精和伊红染色、地衣红染色以及过碘酸希夫染色法。
藏红花对正常血压大鼠无影响，但对高血压大鼠，从治疗第三周起可防止血压升高（P<0.001）。此外，藏红花减小了主动脉的横截面积、中膜厚度和弹性板层数（P<0.05）。
营养型藏红花可防止高血压大鼠血压升高和主动脉重塑。它可能对预防高血压有用。
