Imenshahidi Mohsen, Razavi Bibi Marjan, Faal Ayyoob, Gholampoor Ali, Mousavi Seyed Mehran, Hosseinzadeh Hossein
Pharmaceutical Research Center, Department of Pharmacodynamy and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Targeted Drug Delivery Research Center, Department of Pharmacodynamy and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Iran J Pharm Res. 2015 Spring;14(2):585-90.
Safranal, the main component of Crocus sativus essential oil, exhibits different pharmacological activities. In this study, the effects of safranal, on blood pressure of normotensive and desoxycorticosterone acetate (DOCA) - salt induced hypertensive rats in chronic administration were investigated. Three doses of safranal (1, 2 and 4 mg/Kg/day) and spironolactone (50 mg/Kg/day) were administrated to the different groups of normotensive and hypertensive rats (at the end of 4 weeks treatment by DOCA-salt) for Five weeks. Then the effects of safranal on mean systolic blood pressure (MSBP) and heart rate (HR) were evaluated using tail cuff method. The duration of effect of safranal on SBP, was also evaluated. Our results indicated that chronic administration of safranal could reduce the MSBP in DOCA salt treated rats in a dose dependent manner. Safranal did not decrease the MSBP in normotensive rats. The data also showed that antihypertensive effects of safranal did not persist. In summary, our results showed that safranal exhibits antihypertensive and normalizing effect on BP in chronic administration.
藏红花醛是藏红花精油的主要成分，具有多种药理活性。本研究考察了长期给药时藏红花醛对正常血压大鼠以及醋酸脱氧皮质酮（DOCA）-盐诱导的高血压大鼠血压的影响。将不同剂量的藏红花醛（1、2和4mg/kg/天）和螺内酯（50mg/kg/天）分别给予正常血压和高血压大鼠不同组（在DOCA-盐处理4周结束时），持续给药5周。然后采用尾套法评估藏红花醛对平均收缩压（MSBP）和心率（HR）的影响。还评估了藏红花醛对收缩压（SBP）的作用持续时间。我们的结果表明，长期给予藏红花醛可使DOCA-盐处理的大鼠的MSBP呈剂量依赖性降低。藏红花醛对正常血压大鼠的MSBP没有降低作用。数据还显示，藏红花醛的降压作用不能持续。总之，我们的结果表明，长期给药时藏红花醛对血压具有降压和使其恢复正常的作用。
