Reinblatt Shauna P
Department of Psychiatry and Behavioral Sciences, Division of Child Psychiatry, Johns Hopkins University School of Medicine, 550 North Broadway, Room 206 D, Baltimore, MD, 21205, USA,
Curr Treat Options Psychiatry. 2015 Dec;2(4):402-412. doi: 10.1007/s40501-015-0060-7. Epub 2015 Oct 9.
Attention deficit/hyperactivity disorder (ADHD) is a disorder characterized by impulsivity, hyperactivity, and inattention. Binge-eating behavior is often impulsive and is the hallmark of the two eating disorders, binge-eating disorder (BED) and bulimia nervosa (BN), both of which are associated with significant health impairment. Bingeing behavior is also seen in the binge purge subtype of anorexia nervosa. Individuals with AN of the binge purge subtypes, BN and BED, have been found to exhibit impulsive behaviors that are often not limited to binge eating alone. There is preliminary evidence linking ADHD to BN and to BED in both adults and children. The neurobiological mechanisms behind these associations are only beginning to emerge; however, they suggest that impulse control deficits may play a role in these eating disorders. Additionally, although they may not meet full criteria for one of these eating disorders, some adults and children with ADHD present with dysregulated, impulsive eating disorder behaviors and there is a growing association between ADHD, obesity, and binge-eating behavior in both children and adults. The relationship between ADHD and binge eating is novel, supported by growing evidence and worthy of further research. We will review the underlying neurobiological underpinnings, neuroimaging data, and possible psychopharmacological treatment options, which target both ADHD and binge-eating behaviors as well as future research and treatment directions.
注意力缺陷多动障碍(ADHD)是一种以冲动、多动和注意力不集中为特征的疾病。暴饮暴食行为往往是冲动性的,是两种饮食失调症即暴饮暴食症(BED)和神经性贪食症(BN)的标志,这两种疾病都与严重的健康损害有关。在神经性厌食症的暴饮暴食清除亚型中也可见到暴饮暴食行为。已发现患有暴饮暴食清除亚型的神经性厌食症、神经性贪食症和暴饮暴食症的个体表现出冲动行为,且往往不仅限于暴饮暴食。有初步证据表明,ADHD在成人和儿童中都与神经性贪食症和暴饮暴食症有关。这些关联背后的神经生物学机制才刚刚开始显现;然而,它们表明冲动控制缺陷可能在这些饮食失调症中起作用。此外,尽管一些患有ADHD的成人和儿童可能不符合这些饮食失调症之一的全部标准,但他们存在饮食失调、冲动性饮食障碍行为,并且在儿童和成人中,ADHD、肥胖和暴饮暴食行为之间的关联也日益增加。ADHD与暴饮暴食之间的关系是新出现的,有越来越多的证据支持,值得进一步研究。我们将回顾潜在的神经生物学基础、神经影像学数据以及可能的针对ADHD和暴饮暴食行为的精神药理学治疗选择,以及未来的研究和治疗方向。