纳米颗粒-水凝胶：一种用于局部给药的混合生物材料系统。
Nanoparticle-Hydrogel: A Hybrid Biomaterial System for Localized Drug Delivery.
作者信息
Gao Weiwei, Zhang Yue, Zhang Qiangzhe, Zhang Liangfang
机构信息
Department of Nanoengineering and Moores Cancer Center, University of California, San Diego, La Jolla, CA, 92093, USA.
出版信息
Ann Biomed Eng. 2016 Jun;44(6):2049-61. doi: 10.1007/s10439-016-1583-9. Epub 2016 Mar 7.
Nanoparticles have offered a unique set of properties for drug delivery including high drug loading capacity, combinatorial delivery, controlled and sustained drug release, prolonged stability and lifetime, and targeted delivery. To further enhance therapeutic index, especially for localized application, nanoparticles have been increasingly combined with hydrogels to form a hybrid biomaterial system for controlled drug delivery. Herein, we review recent progresses in engineering such nanoparticle-hydrogel hybrid system (namely 'NP-gel') with a particular focus on its application for localized drug delivery. Specifically, we highlight four research areas where NP-gel has shown great promises, including (1) passively controlled drug release, (2) stimuli-responsive drug delivery, (3) site-specific drug delivery, and (4) detoxification. Overall, integrating therapeutic nanoparticles with hydrogel technologies creates a unique and robust hybrid biomaterial system that enables effective localized drug delivery.
纳米颗粒为药物递送提供了一系列独特的特性，包括高药物负载能力、组合递送、可控和持续药物释放、延长的稳定性和寿命以及靶向递送。为了进一步提高治疗指数，特别是对于局部应用，纳米颗粒已越来越多地与水凝胶结合，形成用于可控药物递送的混合生物材料系统。在此，我们综述了工程化这种纳米颗粒-水凝胶混合系统（即“NP-凝胶”）的最新进展，特别关注其在局部药物递送中的应用。具体而言，我们重点介绍了NP-凝胶显示出巨大潜力的四个研究领域，包括（1）被动控制药物释放、（2）刺激响应性药物递送、（3）位点特异性药物递送和（4）解毒。总体而言，将治疗性纳米颗粒与水凝胶技术相结合，创造了一种独特而强大的混合生物材料系统，能够实现有效的局部药物递送。
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