Kang Min-Ho, Jang Tae-Sik, Kim Sung Won, Park Hui-Sun, Song Juha, Kim Hyoun-Ee, Jung Kyung-Hwan, Jung Hyun-Do
Department of Materials Science and Engineering, Seoul National University, Seoul 151-744, Republic of Korea.
Department of Materials Science and Engineering, Seoul National University, Seoul 151-744, Republic of Korea; Advanced Institutes of Convergence Technology, Seoul National University, Suwon-si 443-270, Republic of Korea.
Mater Sci Eng C Mater Biol Appl. 2016 May;62:634-42. doi: 10.1016/j.msec.2016.01.085. Epub 2016 Jan 30.
Porous magnesium (Mg) has recently emerged as a promising biodegradable alternative to biometal for bone ingrowth; however, its low mechanical properties and high corrosion rate in biological environments remain problematic. In this study, porous magnesium was implemented in a scaffold that closely mimics the mechanical properties of human bones with a controlled degradation rate and shows good biocompatibility to match the regeneration rate of bone tissue at the affected site. The alumina-reinforced Mg scaffold was produced by spark plasma sintering and coated with magnesium fluoride (MgF2) using a hydrofluoric acid solution to regulate the corrosion rate under physiological conditions. Sodium chloride granules (NaCl), acting as space holders, were leached out to achieve porous samples (60%) presenting an average pore size of 240 μm with complete pore interconnectivity. When the alumina content increased from 0 to 5 vol%, compressive strength and stiffness rose considerably from 9.5 to 13.8 MPa and from 0.24 to 0.40 GPa, respectively. Moreover, the biological response evaluated by in vitro cell test and blood test of the MgF2-coated porous Mg composite was enhanced with better corrosion resistance compared with that of uncoated counterparts. Consequently, MgF2-coated porous Mg/alumina composites may be applied in load-bearing biodegradable implants.
多孔镁（Mg）最近已成为一种有前景的可生物降解的生物金属替代物，用于骨长入；然而，其在生物环境中的低机械性能和高腐蚀速率仍然是问题。在本研究中，多孔镁被应用于一种支架中，该支架紧密模拟人体骨骼的机械性能，具有可控的降解速率，并表现出良好的生物相容性，以匹配受影响部位骨组织的再生速率。氧化铝增强的镁支架通过放电等离子烧结制备，并使用氢氟酸溶液涂覆氟化镁（MgF2）以调节生理条件下的腐蚀速率。作为空间支撑体的氯化钠颗粒（NaCl）被浸出，以获得孔隙率为60%的多孔样品，其平均孔径为240μm，且孔隙完全连通。当氧化铝含量从0增加到5体积%时，抗压强度和刚度分别从9.5MPa显著提高到13.8MPa，从0.24GPa提高到0.40GPa。此外，与未涂层的对应物相比，通过体外细胞测试和血液测试评估的MgF2涂层多孔镁复合材料的生物反应得到增强，且具有更好的耐腐蚀性。因此，MgF2涂层多孔镁/氧化铝复合材料可应用于承重可生物降解植入物。
