Scheffer Christian, Debus Marion, Heckmann Christian, Cysarz Dirk, Girke Matthias
Integrated Curriculum for Anthroposophic Medicine, Institute for Integrative Medicine, Faculty for Health, Department for Medicine, Alfred-Herrhausen-Straße 50, 58448 Witten, Germany; Gemeinschaftskrankenhaus Herdecke, Department for Internal Medicine, Gerhard-Kienle-Weg 4, 58313 Herdecke, Germany.
Research Institute Havelhöhe, Kladower Damm 221, 14089 Berlin, Germany; Department of Internal Medicine, Havelhöhe Hospital, Kladower Damm 221, 14089 Berlin, Germany.
Evid Based Complement Alternat Med. 2016;2016:2541912. doi: 10.1155/2016/2541912. Epub 2016 Feb 3.
Introduction. Goitre with euthyroid function or with subclinical or mild hyperthyroidism due to thyroid autonomy is common. In anthroposophic medicine various thyroid disorders are treated with Colchicum autumnale (CAU). We examined the effects of CAU in patients with goitre of both functional states. Patients and methods. In an observational study, 24 patients with goitre having suppressed thyroid stimulating hormone (TSH) levels with normal or slightly elevated free thyroxine (fT4) and free triiodothyronine (fT3) (group 1, n = 12) or normal TSH, fT3, and fT4 (group 2, n = 12) were included. After 3 months and after 6 to 12 months of CAU treatment, we investigated clinical pathology using the Hyperthyroid Symptom Scale (HSS), hormone status (TSH, fT4, and fT3), and thyroidal volume (tV). Results. After treatment with CAU, in group 1 the median HSS decreased from 4.5 (2.3-11.8) to 2 (1.3-3) (p < 0.01) and fT3 decreased from 3.85 (3.5-4.78) to 3.45 (3.3-3.78) pg/mL (p < 0.05). In group 2 tV (13.9% (18.5%-6.1%)) and TSH (p < 0.01) were reduced. Linear regression for TSH and fT3 in both groups indicated a regulative therapeutic effect of CAU. Conclusions. CAU positively changed the clinical pathology of subclinical hyperthyroidism and thyroidal volume in patients with euthyroid goitre by normalization of the regulation of thyroidal hormones.
引言。甲状腺功能正常或因甲状腺自主性导致亚临床或轻度甲状腺功能亢进的甲状腺肿很常见。在人智医学中，各种甲状腺疾病都用秋水仙（CAU）进行治疗。我们研究了CAU对两种功能状态甲状腺肿患者的影响。
患者与方法。在一项观察性研究中，纳入了24例甲状腺肿患者，其中12例患者促甲状腺激素（TSH）水平被抑制，游离甲状腺素（fT4）和游离三碘甲状腺原氨酸（fT3）正常或略有升高（第1组），另外12例患者TSH、fT3和fT4正常（第2组）。在CAU治疗3个月后以及6至12个月后，我们使用甲状腺功能亢进症状量表（HSS）、激素状态（TSH、fT4和fT3）以及甲状腺体积（tV）来研究临床病理情况。
结果。CAU治疗后，第1组中HSS的中位数从4.5（2.3 - 11.8）降至2（1.3 - 3）（p < 0.01），fT3从3.85（3.5 - 4.78）降至3.45（3.3 - 3.78）pg/mL（p < 0.05）。在第2组中，tV（13.9%（18.5% - 6.1%））和TSH（p < 0.01）降低。两组中TSH和fT3的线性回归表明CAU具有调节治疗作用。
结论。CAU通过使甲状腺激素调节正常化，对甲状腺功能正常的甲状腺肿患者的亚临床甲状腺功能亢进临床病理和甲状腺体积产生了积极影响。
