Rath Jakob, Wurnig Moritz, Fischmeister Florian, Klinger Nicolaus, Höllinger Ilse, Geißler Alexander, Aichhorn Markus, Foki Thomas, Kronbichler Martin, Nickel Janpeter, Siedentopf Christian, Staffen Wolfgang, Verius Michael, Golaszewski Stefan, Koppelstaetter Florian, Auff Eduard, Felber Stephan, Seitz Rüdiger J, Beisteiner Roland
Department of Neurology and MR Center of Excellence, Medical University of Vienna, Austria.
Centre for Cognitive Neuroscience, University of Salzburg, Salzburg, Austria.
Hum Brain Mapp. 2016 Jun;37(6):2151-60. doi: 10.1002/hbm.23162. Epub 2016 Mar 9.
This study provides first data about the spatial variability of fMRI sensorimotor localizations when investigating the same subjects at different fMRI sites. Results are comparable to a previous patient study. We found a median between-site variability of about 6 mm independent of task (motor or sensory) and experimental standardization (high or low). An intraclass correlation coefficient analysis using data quality measures indicated a major influence of the fMRI site on variability. In accordance with this, within-site localization variability was considerably lower (about 3 mm). We conclude that the fMRI site is a considerable confound for localization of brain activity. However, when performed by experienced clinical fMRI experts, brain pathology does not seem to have a relevant impact on the reliability of fMRI localizations. Hum Brain Mapp 37:2151-2160, 2016. © 2016 Wiley Periodicals, Inc.
本研究首次提供了关于在不同功能磁共振成像（fMRI）站点对同一受试者进行研究时，fMRI感觉运动定位空间变异性的数据。结果与之前的一项患者研究相当。我们发现，与任务（运动或感觉）和实验标准化（高或低）无关，站点间变异性的中位数约为6毫米。使用数据质量指标的组内相关系数分析表明，fMRI站点对变异性有重大影响。据此，站点内定位变异性显著更低（约3毫米）。我们得出结论，fMRI站点是脑活动定位的一个相当大的混杂因素。然而，当由经验丰富的临床fMRI专家进行操作时，脑部病变似乎对fMRI定位的可靠性没有相关影响。《人类脑图谱》37:2151 - 2160，2016年。© 2016威利期刊公司
