Chan Kenneth H, Tom Henry, Lee Robert C, Kang Hobin, Simon Jacob C, Staninec Michal, Darling Cynthia L, Pelzner Roger B, Fried Daniel
University of California, San Francisco, San Francisco, California, 94143-0758.
Lasers Surg Med. 2016 Dec;48(10):915-923. doi: 10.1002/lsm.22500. Epub 2016 Mar 9.
Studies have shown that cross-polarization optical coherence tomography (CP-OCT) can be used to image the internal structure of carious lesions in vivo. The objective of this study was to show that CP-OCT can be used to monitor changes in the internal structure of early active carious lesions on smooth surfaces during non-surgical intervention with fluoride.
Lesions on the smooth surfaces of teeth were imaged using CP-OCT on 17 test subjects. Lesion structural changes were monitored during fluoride varnish application at 6-week intervals for 30 weeks. The lesion depth (L ), integrated reflectivity (ΔR), and surface zone thickness (S ) were monitored.
A distinct transparent surface zone that may be indicative of lesion arrestment was visible in CP-OCT images on 62/63 lesions before application of fluoride varnish. The lesion depth and internal structure were resolved for all the lesions. The overall change in the mean values for L , ΔR, and S for all the lesions was minimal and was not significant during the study (P > 0.05). Only 5/63 lesions manifested a significant increase in S during intervention.
Even though it appears that most of the lesions manifested little change with fluoride varnish application in the 30 weeks of the study, CP-OCT was able to measure the depth and internal structure of all the lesions including the thickness of the important transparent surface zone located at the surface of the lesions, indicating that CP-OCT is ideally suited for monitoring lesion severity in vivo. Lasers Surg. Med. 48:915-923, 2016. © 2016 Wiley Periodicals, Inc.
研究表明，交叉极化光学相干断层扫描（CP - OCT）可用于在体内对龋损的内部结构进行成像。本研究的目的是表明CP - OCT可用于监测在使用氟化物进行非手术干预期间光滑表面早期活动性龋损内部结构的变化。
对17名受试对象的牙齿光滑表面的病损使用CP - OCT进行成像。在30周内每隔6周涂抹氟化物漆期间监测病损结构变化。监测病损深度（L）、积分反射率（ΔR）和表面区厚度（S）。
在涂抹氟化物漆之前，在62/63个病损的CP - OCT图像中可见一个可能指示病损停止发展的明显透明表面区。所有病损的病损深度和内部结构都得到了解析。在研究期间，所有病损的L、ΔR和S的平均值总体变化很小且无统计学意义（P > 0.05）。在干预期间，只有5/63个病损的S出现了显著增加。
尽管在该研究的30周内，大多数病损在涂抹氟化物漆后似乎变化不大，但CP - OCT能够测量所有病损的深度和内部结构，包括位于病损表面的重要透明表面区的厚度，这表明CP - OCT非常适合在体内监测病损严重程度。《激光外科与医学》48:915 - 923，2016年。© 2016威利期刊公司
