Hou Xiao-Yang, Jiang Guan, Yang Chun-Sheng, Tang Jian-Qin, Wei Zhi-Ping, Liu Yan-Qun
Dermatology Department, Affiliated Hospital of Xuzhou Medical College, Xuzhou 221002, Jiangsu P.R. China.
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Recent Pat Anticancer Drug Discov. 2016;11(3):322-31. doi: 10.2174/1574892811666160309121035.
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide. However, the inherent limitations of traditional surgery and insensitivity to radiation and chemotherapy result in failing treatment and poor prognosis. In recent years, the development and advances of nanotechnology has brought new hope for the diagnosis and treatment of HCC. This article reviews the development of nanoparticles used for cancer detection, diagnosis and treatment due to their large specific surface area and unique optical, electronic and magnetic properties. Moreover, studies have shown that after intended surface modification, nano-carriers can achieve active targeting effect, which improves the efficiency of chemotherapeutic drugs and decreases their side effects. In this review, we provide an overview of these studies results, patents about novel nanomaterials and conclude with a discussion about future development.
肝细胞癌（HCC）是全球最常见的恶性肿瘤之一。然而，传统手术的固有局限性以及对放疗和化疗的不敏感性导致治疗失败和预后不良。近年来，纳米技术的发展与进步为HCC的诊断和治疗带来了新希望。本文综述了由于纳米颗粒具有大比表面积以及独特的光学、电学和磁学性质而用于癌症检测、诊断和治疗的研究进展。此外，研究表明，经过特定的表面修饰后，纳米载体可实现主动靶向作用，从而提高化疗药物的疗效并降低其副作用。在本综述中，我们概述了这些研究结果、新型纳米材料的专利，并对未来发展进行了讨论。
