Mohamed Nourhan K, Hamad Mostafa A, Hafez Mohamed Z E, Wooley Karen L, Elsabahy Mahmoud
Assiut International Center of Nanomedicine, Al-Rajhy Liver Hospital, Assiut University, Egypt.
Department of Surgery, Faculty of Medicine, Assiut University, Egypt.
Int J Cancer. 2017 Apr 1;140(7):1475-1484. doi: 10.1002/ijc.30517. Epub 2016 Dec 2.
Hepatocellular carcinoma is the second leading cause of cancer deaths worldwide. It is characterized by unique features that can be utilized for selective and targeted therapy, which aids in preserving healthy tissues from deteriorating effects of traditional chemotherapeutics. In this minireview, a brief overview of recent drug delivery attempts for the management of hepatocellular carcinoma with the aid of nanomedical structures is presented. The beneficial impact of nanomaterials in terms of prolonged retention in blood and target sites, controlled biodistribution and improved stability of the encapsulated payloads, will be described, together with the possibility of incorporating more than one cargo into the same nanostructure. Incorporation of stimuli-responsive components, decoration with targeting moieties and the use of molecularly targeted drugs for treatment of hepatocellular carcinoma are also highlighted.
肝细胞癌是全球癌症死亡的第二大主要原因。它具有独特的特征，可用于选择性和靶向治疗，这有助于保护健康组织免受传统化疗药物的不良影响。在这篇小型综述中，简要概述了借助纳米医学结构治疗肝细胞癌的近期药物递送尝试。将描述纳米材料在血液和靶位点的延长保留、可控的生物分布以及提高封装药物的稳定性方面的有益影响，以及在同一纳米结构中纳入多种药物的可能性。还强调了纳入刺激响应成分、用靶向部分进行修饰以及使用分子靶向药物治疗肝细胞癌的情况。
