Sun Haoran, Song Tianqiang
Department of Radiology, Tianjin Medical University Hospital.
Drug Discov Ther. 2015 Oct;9(5):310-8. doi: 10.5582/ddt.2015.01058.
Thanks to the growing knowledge on biological behaviors of hepatocellular carcinomas (HCC), as well as continuous improvement in imaging techniques and experienced interpretation of imaging features of the nodules in cirrhotic liver, the detection and characterization of HCC has improved in the past decade. A number of practice guidelines for imaging diagnosis have been developed to reduce interpretation variability and standardize management of HCC, and they are constantly updated with advances in imaging techniques and evidence based data from clinical series. In this article, we strive to review the imaging techniques and the characteristic features of hepatocellular carcinoma associated with cirrhotic liver, with emphasis on the diagnostic value of advanced magnetic resonance imaging (MRI) techniques and utilization of hepatocyte-specific MRI contrast agents. We also briefly describe the concept of liver imaging reporting and data systems and discuss the consensus and controversy of major practice guidelines.
得益于对肝细胞癌（HCC）生物学行为的认识不断增加，以及成像技术的持续改进和对肝硬化肝脏结节成像特征的经验性解读，在过去十年中，HCC的检测和特征描述有了改善。已经制定了一些成像诊断实践指南，以减少解读差异并规范HCC的管理，并且随着成像技术的进步和来自临床系列的循证数据不断更新。在本文中，我们力求回顾与肝硬化肝脏相关的肝细胞癌的成像技术和特征，重点是先进磁共振成像（MRI）技术的诊断价值以及肝细胞特异性MRI造影剂的应用。我们还简要描述了肝脏成像报告和数据系统的概念，并讨论主要实践指南的共识和争议。
