Adabimohazab Razieh, Garfinkel Amanda, Milam Emily C, Frosch Olivia, Mangone Alexander, Convit Antonio
Department of Psychiatry, New York University School of Medicine, New York, NY, USA.
Department of Medicine, New York University School of Medicine, New York, NY, USA.
Inflammation. 2016 Jun;39(3):994-1003. doi: 10.1007/s10753-016-0329-z.
In adult obesity, low-grade systemic inflammation is considered an important step in the pathogenesis of insulin resistance (IR). The association between obesity and inflammation is less well established in adolescents. Here, we ascertain the importance of inflammation in IR among obese adolescents by utilizing either random forest (RF) classification or mediation analysis approaches. The inflammation balance score, composed of eight pro- and anti-inflammatory makers, as well as most of the individual inflammatory markers differed significantly between lean and overweight/obese. In contrast, adiponectin was the only individual marker selected as a predictor of IR by RF, and the balance score only revealed a medium-to-low importance score. Neither adiponectin nor the inflammation balance score was found to mediate the relationship between obesity and IR. These findings do not support the premise that low-grade systemic inflammation is a key for the expression of IR in the human. Prospective longitudinal studies should confirm these findings.
在成人肥胖中，低度全身性炎症被认为是胰岛素抵抗（IR）发病机制中的重要一步。肥胖与炎症之间的关联在青少年中尚未完全明确。在此，我们通过随机森林（RF）分类或中介分析方法来确定炎症在肥胖青少年IR中的重要性。由八种促炎和抗炎标志物组成的炎症平衡评分，以及大多数个体炎症标志物在瘦人与超重/肥胖者之间存在显著差异。相比之下，脂联素是RF选择的唯一作为IR预测指标的个体标志物，且平衡评分仅显示出中低重要性评分。未发现脂联素和炎症平衡评分介导肥胖与IR之间的关系。这些发现不支持低度全身性炎症是人类IR表达关键的前提。前瞻性纵向研究应证实这些发现。
